Exploring the Molecular Complexity of Triatoma Dimidiata Sialome

Overview

Journal J Proteomics

Publisher Elsevier

Specialty Biochemistry

Date 2017 Dec 31

PMID 29288089

Citations 7

Authors

Paula Beatriz Santiago

Carla Nunes de Araujo

Sebastien Charneau

Izabela Marques Dourado Bastos

Teresa Cristina F Assumpcao

Rayner Myr Lauterjung Queiroz

Yanna Reis Praca

Thuany de Moura Cordeiro

Carlos Henrique Saraiva Garcia

Ionizete Garcia da Silva

Taina Raiol

Flavia Nader Motta

Joao Victor de Araujo Oliveira

Marcelo Valle de Sousa

Jose Marcos C Ribeiro

Jaime Martins de Santana

Affiliations

Soon will be listed here.

Abstract

Significance: Several haematophagous triatomine species can transmit Trypanosoma cruzi, the etiological agent of Chagas disease. Due to the reemergence of this disease, new drugs for its prevention and treatment are considered priorities. For this reason, the knowledge of vector saliva emerges as relevant biological finding, contributing to the design of different strategies for vector control and disease transmission. Here we report the transcriptomic and proteomic compositions of the salivary glands (sialome) of the reduviid bug Triatoma dimidiata, a relevant Chagas disease vector in Central America. Our results are robust and disclosed unprecedented insights into the notable diversity of its salivary glands content, revealing relevant anti-haemostatic salivary gene families. Our work expands almost ten times the previous set of functionally annotated sequences from T. dimidiata salivary glands available in NCBI. Moreover, using an integrated transcriptomic and proteomic approach, we showed a correlation pattern of transcription and translation processes for the main gene families found, an important contribution to the research of triatomine sialomes. Furthermore, data generated here reinforces the secreted proteins encountered can greatly contribute for haematophagic habit, Trypanosoma cruzi transmission and development of therapeutic agent studies.

Citing Articles

Interaction of , Triatomines and the Microbiota of the Vectors-A Review.

Schaub G Microorganisms. 2024; 12(5).

PMID: 38792688 PMC: 11123833. DOI: 10.3390/microorganisms12050855.

The biotechnological potential of proteases from hematophagous arthropod vectors.

de Araujo C, Santiago P, Causin Vieira G, Silva G, Moura R, Bastos I Front Cell Infect Microbiol. 2023; 13:1287492.

PMID: 37965257 PMC: 10641018. DOI: 10.3389/fcimb.2023.1287492.

Population genomics and geographic dispersal in Chagas disease vectors: Landscape drivers and evidence of possible adaptation to the domestic setting.

Hernandez-Castro L, Villacis A, Jacobs A, Cheaib B, Day C, Ocana-Mayorga S PLoS Genet. 2022; 18(2):e1010019.

PMID: 35120121 PMC: 8849464. DOI: 10.1371/journal.pgen.1010019.

An Integrative Sialomic Analysis Reveals Molecules From (Hemiptera: Reduviidae).

Praca Y, Santiago P, Charneau S, Mandacaru S, Bastos I, da Silva Bentes K Front Cell Infect Microbiol. 2022; 11:798924.

PMID: 35047420 PMC: 8762107. DOI: 10.3389/fcimb.2021.798924.

Salivary and Intestinal Transcriptomes Reveal Differential Gene Expression in Starving, Fed and -Infected .

Carvalho-Costa T, Tiveron R, Mendes M, Barbosa C, Nevoa J, Roza G Front Cell Infect Microbiol. 2022; 11:773357.

PMID: 34988032 PMC: 8722679. DOI: 10.3389/fcimb.2021.773357.

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