Immune Responses to Congenital Cytomegalovirus Infection

Overview

Journal Microbes Infect

Publisher Elsevier

Specialties Allergy & Immunology
Microbiology

Date 2017 Dec 31

PMID 29287989

Citations 23

Authors

Ilija Brizic

Lea Hirsl

William J Britt

Astrid Krmpotic

Stipan Jonjic

Affiliations

Soon will be listed here.

Abstract

Human cytomegalovirus (HCMV) is the most common cause of viral infection acquired in utero. Even though the infection has been studied for several decades, immune determinants important for virus control and mechanisms of long-term sequelae caused by infection are still insufficiently characterized. Animal models of congenital HCMV infection provide unique opportunity to study various aspects of human disease. In this review, we summarize current knowledge on the role of immune system in congenital CMV infection, with emphasis on lessons learned from mouse model of congenital CMV infection.

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