Bacteria from Bronchoalveolar Lavage Fluid from Children with Suspected Chronic Lower Respiratory Tract Infection: Results from a Multi-center, Cross-sectional Study in Spain

Overview

Journal Eur J Pediatr

Specialty Pediatrics

Date 2017 Dec 30

PMID 29285648

Citations 13

Authors

Amparo Escribano Montaner

Juan Garcia de Lomas

Jose Ramon Villa Asensi

Oscar Asensio de la Cruz

Olga de la Serna Blazquez

Mikel Santiago Burruchaga

Pedro Mondejar Lopez

Alba Torrent Vernetta

Yang Feng

Melissa K Van Dyke

Janet Reyes

Pilar Garcia-Corbeira

Carla A Talarico

Affiliations

Soon will be listed here.

Abstract

Conclusion: S. pneumoniae, NTHi, and M. catarrhalis were the main bacteria detected in BALF and NPS. Children with suspected chronic LRTI may benefit from a vaccine protecting against NTHi. What is Known: • Chronic lower respiratory tract infection (LRTI) in children can cause high morbidity and is a major use of healthcare resources worldwide. Despite this, their etiology or potential preventive measures are poorly assessed. • Bronchoalveolar lavage can be used to determine bacterial etiology of chronic LRTI. What is New: • We used conventional and molecular techniques to show that Haemophilus influenzae, Streptococcus pneumoniae, and Moraxella catarrhalis were present in the LRT of Spanish children with suspected chronic LRTI • Concordance between isolates from bronchoalveolar lavage fluid and nasopharyngeal swabs was low, suggesting that samples from the upper respiratory tract could not reliably predict the bacterial etiology of suspected chronic LRTI.

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