Rs360719 A>G, Rs13015714 G>T, Rs917997 C>T and Rs8099917 T>G Polymorphisms and Risk of Gastric Cardiac Adenocarcinoma

Overview

Journal Mol Clin Oncol

Specialty Oncology

Date 2017 Dec 30

PMID 29285382

Authors

Jun Yin

Changqing Dong

Weifeng Tang

Ruiping Liu

Suocheng Chen

Liang Zheng

Haiyong Gu

Affiliations

Soon will be listed here.

Abstract

The present study was conducted to investigate the association between gastric cardiac adenocarcinoma (GCA) and four functional single-nucleotide polymorphisms (SNPs), including interleukin 18 () rs360719 A>G, IL18 receptor 1 rs13015714 G>T, IL18 receptor accessory protein rs917997 C>T and interleukin 28B rs8099917 T>G variants. A hospital-based case-control study was performed to evaluate the genetic effects of these SNPs. A total of 243 GCA cases and 476 controls were enrolled in this study. A custom-by-design 48-Plex SNPscan™ kit was used to determine the genotypes. When the rs360719 AA homozygote genotype was used as the reference group, the AG genotype was not associated with the risk for GCA; the GG genotype was also not associated with the risk for GCA. In the dominant model, the rs360719 AG/GG variants were not associated with the risk for GCA, compared with the rs360719 AA genotype. In the recessive model, when the rs13015714 AA/AG genotypes were used as the reference group, the GG homozygote genotype was not associated with risk for GCA. No association was observed between rs13015714 G>T, rs917997 C>T and rs8099917 T>G polymorphisms and the risk for GCA. These results demonstrated that the functional polymorphisms rs360719 A>G, rs13015714 G>T, rs917997 C>T and rs8099917 T>G do not contribute to GCA susceptibility. However, as the statistical power of our study was limited, large well-designed studies and further functional investigations are required to confirm our findings.

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