Crosstalk Between the Notch Signaling Pathway and Non-coding RNAs in Gastrointestinal Cancers

Overview

Journal Oncol Lett

Specialty Oncology

Date 2017 Dec 30

PMID 29285185

Citations 3

Authors

Yangyang Pan

Yuyan Mao

Rong Jin

Lei Jiang

Affiliations

Soon will be listed here.

Abstract

The Notch signaling pathway is one of the main signaling pathways that mediates direct contact between cells, and is essential for normal development. It regulates various cellular processes, including cell proliferation, apoptosis, migration, invasion, angiogenesis and metastasis. It additionally serves an important function in tumor progression. Non-coding RNAs mainly include small microRNAs, long non-coding RNAs and circular RNAs. At present, a large body of literature supports the biological significance of non-coding RNAs in tumor progression. It is also becoming increasingly evident that cross-talk exists between Notch signaling and non-coding RNAs. The present review summarizes the current knowledge of Notch-mediated gastrointestinal cancer cell processes, and the effect of the crosstalk between the three major types of non-coding RNAs and the Notch signaling pathway on the fate of gastrointestinal cancer cells.

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