Meningioma Growth Dynamics Assessed by Radiocarbon Retrospective Birth Dating

Overview

Journal EBioMedicine

Specialty Biomedical Engineering

Date 2017 Dec 27

PMID 29277322

Citations 9

Authors

Hagen B Huttner

Olaf Bergmann

Mehran Salehpour

Raouf El Cheikh

Makoto Nakamura

Angelo Tortora

Paula Heinke

Roland Coras

Elisabet Englund

Ilker Y Eyupoglu

Joji B Kuramatsu

Sebastian S Roeder

Stephan P Kloska

Iris Muehlen

Arnd Doerfler

Stefan Schwab

Goran Possnert

Samuel Bernard

Jonas Frisen

Affiliations

Soon will be listed here.

Abstract

It is not known how long it takes from the initial neoplastic transformation of a cell to the detection of a tumor, which would be valuable for understanding tumor growth dynamics. Meningiomas show a broad histological, genetic and clinical spectrum, are usually benign and considered slowly growing. There is an intense debate regarding their age and growth pattern and when meningiomas should be resected. We have assessed the age and growth dynamics of 14 patients with meningiomas (WHO grade I: n=6 with meningothelial and n=6 with fibrous subtype, as well as n=2 atypical WHO grade II meningiomas) by combining retrospective birth-dating of cells by analyzing incorporation of nuclear-bomb-test-derived C, analysis of cell proliferation, cell density, MRI imaging and mathematical modeling. We provide an integrated model of the growth dynamics of benign meningiomas. The mean age of WHO grade I meningiomas was 22.1±6.5years, whereas atypical WHO grade II meningiomas originated 1.5±0.1years prior to surgery (p<0.01). We conclude that WHO grade I meningiomas are very slowly growing brain tumors, which are resected in average two decades after time of origination.

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