Sensing and Signaling Mechanisms Linking Dietary Methionine Restriction to the Behavioral and Physiological Components of the Response

Overview

Journal Front Neuroendocrinol

Specialty Endocrinology

Date 2017 Dec 25

PMID 29274999

Citations 10

Authors

Laura A Forney

Kirsten P Stone

Desiree Wanders

Thomas W Gettys

Affiliations

Soon will be listed here.

Abstract

Dietary methionine restriction (MR) is implemented using a semi-purified diet that reduces methionine by ∼80% and eliminates dietary cysteine. Within hours of its introduction, dietary MR initiates coordinated series of transcriptional programs and physiological responses that include increased energy intake and expenditure, decreased adiposity, enhanced insulin sensitivity, and reduction in circulating and tissue lipids. Significant progress has been made in cataloguing the physiological responses to MR in males but not females, but identities of the sensing and communication networks that orchestrate these responses remain poorly understood. Recent work has implicated hepatic FGF21 as an important mediator of MR, but it is clear that other mechanisms are also involved. The goal of this review is to explore the temporal and spatial organization of the responses to dietary MR as a model for understanding how nutrient sensing systems function to integrate complex transcriptional, physiological, and behavioral responses to changes in dietary composition.

Citing Articles

Dietary Methionine and Total Sulfur Amino Acid Restriction in Healthy Adults.

Richie Jr J, Sinha R, Dong Z, Nichenametla S, Ables G, Ciccarella A J Nutr Health Aging. 2023; 27(2):111-123.

PMID: 36806866 PMC: 10782544. DOI: 10.1007/s12603-023-1883-3.

FGF21 controls hepatic lipid metabolism via sex-dependent interorgan crosstalk.

Chaffin A, Larson K, Huang K, Wu C, Godoroja N, Fang Y JCI Insight. 2022; 7(19).

PMID: 35998055 PMC: 9675565. DOI: 10.1172/jci.insight.155848.

A Study on How Methionine Restriction Decreases the Body's Hepatic and Lipid Deposition in Rice Field Eel ().

Hu Y, Cai M, Zhong H, Chu W, Hu Y Int J Mol Sci. 2021; 22(24).

PMID: 34948174 PMC: 8705440. DOI: 10.3390/ijms222413379.

Nutritional Regulation of Hepatic FGF21 by Dietary Restriction of Methionine.

Fang H, Stone K, Forney L, Wanders D, Gettys T Front Endocrinol (Lausanne). 2021; 12:773975.

PMID: 34917032 PMC: 8669746. DOI: 10.3389/fendo.2021.773975.

The Role of Reduced Methionine in Mediating the Metabolic Responses to Protein Restriction Using Different Sources of Protein.

Fang H, Stone K, Ghosh S, Forney L, Gettys T Nutrients. 2021; 13(8).

PMID: 34444768 PMC: 8399679. DOI: 10.3390/nu13082609.

References

Goto S, Nagao K, Bannai M, Takahashi M, Nakahara K, Kangawa K . Anorexia in rats caused by a valine-deficient diet is not ameliorated by systemic ghrelin treatment. Neuroscience. 2009; 166(1):333-40. DOI: 10.1016/j.neuroscience.2009.12.013. View

Ross-Inta C, Zhang Y, Almendares A, Giulivi C . Threonine-deficient diets induced changes in hepatic bioenergetics. Am J Physiol Gastrointest Liver Physiol. 2009; 296(5):G1130-9. PMC: 2696218. DOI: 10.1152/ajpgi.90545.2008. View

Cheng Y, Meng Q, Wang C, Li H, Huang Z, Chen S . Leucine deprivation decreases fat mass by stimulation of lipolysis in white adipose tissue and upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue. Diabetes. 2009; 59(1):17-25. PMC: 2797918. DOI: 10.2337/db09-0929. View

Elshorbagy A, Valdivia-Garcia M, Mattocks D, Plummer J, Orentreich D, Orentreich N . Effect of taurine and N-acetylcysteine on methionine restriction-mediated adiposity resistance. Metabolism. 2012; 62(4):509-17. DOI: 10.1016/j.metabol.2012.10.005. View

Loh K, Deng H, Fukushima A, Cai X, Boivin B, Galic S . Reactive oxygen species enhance insulin sensitivity. Cell Metab. 2009; 10(4):260-72. PMC: 2892288. DOI: 10.1016/j.cmet.2009.08.009. View

L Bookout A, de Groot M, Owen B, Lee S, Gautron L, Lawrence H . FGF21 regulates metabolism and circadian behavior by acting on the nervous system. Nat Med. 2013; 19(9):1147-52. PMC: 3769420. DOI: 10.1038/nm.3249. View

Forney L, Wanders D, Stone K, Pierse A, Gettys T . Concentration-dependent linkage of dietary methionine restriction to the components of its metabolic phenotype. Obesity (Silver Spring). 2017; 25(4):730-738. PMC: 5373958. DOI: 10.1002/oby.21806. View

Xu J, Stanislaus S, Chinookoswong N, Lau Y, Hager T, Patel J . Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects. Am J Physiol Endocrinol Metab. 2009; 297(5):E1105-14. DOI: 10.1152/ajpendo.00348.2009. View

Solon-Biet S, Mitchell S, Coogan S, Cogger V, Gokarn R, McMahon A . Dietary Protein to Carbohydrate Ratio and Caloric Restriction: Comparing Metabolic Outcomes in Mice. Cell Rep. 2015; 11(10):1529-34. PMC: 4472496. DOI: 10.1016/j.celrep.2015.05.007. View

10.

Raubenheimer D, Simpson S . Integrative models of nutrient balancing: application to insects and vertebrates. Nutr Res Rev. 2008; 10(1):151-79. DOI: 10.1079/NRR19970009. View

11.

Harding H, Zhang Y, Zeng H, Novoa I, Lu P, Calfon M . An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell. 2003; 11(3):619-33. DOI: 10.1016/s1097-2765(03)00105-9. View

12.

Simpson S, Raubenheimer D . Geometric analysis of macronutrient selection in the rat. Appetite. 1997; 28(3):201-13. DOI: 10.1006/appe.1996.0077. View

13.

Ding X, Boney-Montoya J, Owen B, L Bookout A, Coate K, Mangelsdorf D . βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism. Cell Metab. 2012; 16(3):387-93. PMC: 3447537. DOI: 10.1016/j.cmet.2012.08.002. View

14.

Anthony T, McDaniel B, Byerley R, McGrath B, Cavener D, McNurlan M . Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2. J Biol Chem. 2004; 279(35):36553-61. DOI: 10.1074/jbc.M404559200. View

15.

Xia T, Cheng Y, Zhang Q, Xiao F, Liu B, Chen S . S6K1 in the central nervous system regulates energy expenditure via MC4R/CRH pathways in response to deprivation of an essential amino acid. Diabetes. 2012; 61(10):2461-71. PMC: 3447917. DOI: 10.2337/db11-1278. View

16.

Visweswaraiah J, Lageix S, Castilho B, Izotova L, Kinzy T, Hinnebusch A . Evidence that eukaryotic translation elongation factor 1A (eEF1A) binds the Gcn2 protein C terminus and inhibits Gcn2 activity. J Biol Chem. 2011; 286(42):36568-79. PMC: 3196070. DOI: 10.1074/jbc.M111.248898. View

17.

Lee J, Ozcan U . Unfolded protein response signaling and metabolic diseases. J Biol Chem. 2013; 289(3):1203-11. PMC: 3894306. DOI: 10.1074/jbc.R113.534743. View

18.

Holland W, Adams A, Brozinick J, Bui H, Miyauchi Y, Kusminski C . An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice. Cell Metab. 2013; 17(5):790-7. PMC: 3667496. DOI: 10.1016/j.cmet.2013.03.019. View

19.

Maurin A, Jousse C, Averous J, Parry L, Bruhat A, Cherasse Y . The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores. Cell Metab. 2005; 1(4):273-7. DOI: 10.1016/j.cmet.2005.03.004. View

20.

Wilder S, Le Couteur D, Simpson S . Diet mediates the relationship between longevity and reproduction in mammals. Age (Dordr). 2012; 35(3):921-7. PMC: 3636383. DOI: 10.1007/s11357-011-9380-8. View