Increased Postnatal Concentrations of Pro-inflammatory Cytokines Are Associated with Reduced IGF-I Levels and Retinopathy of Prematurity

Overview

Journal Growth Horm IGF Res

Publisher Elsevier

Specialty Endocrinology

Date 2017 Dec 25

PMID 29274846

Citations 30

Authors

Gunnel Hellgren

Chatarina Lofqvist

Ingrid Hansen-Pupp

Magnus Gram

Lois E Smith

David Ley

Ann Hellstrom

Affiliations

Soon will be listed here.

Abstract

Objective: Retinopathy of prematurity (ROP) is a multifactorial disease linked to low insulin-like growth factor (IGF)-I levels and perhaps to postnatal inflammation. Here, we investigated the longitudinal postnatal serum concentrations of pro-inflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)-α in relation to IGF-I levels and ROP.

Design: The study cohort included 52 infants born before 31 gestational weeks. The infants were screened for ROP and classified as non-ROP (n=33), non-proliferative ROP (stages 1 and 2; n=10), or proliferative ROP (stage 3, all treated for ROP; n=9). Blood samples were collected at birth, 24h after birth, and then weekly until at least 36weeks postmenstrual age (PMA) (i.e., up to 13weeks after birth). Circulating levels of IL-6 and TNF-α were evaluated in relation to circulating IGF-I levels and ROP.

Results: IL-6 levels negatively correlated with IGF-I levels between 5 and 8weeks after birth, (p<0.01 to p<0.05). At birth, the IL-6 and TNF-α levels were similar independent of later ROP. Twenty-four hours after birth, both IL-6 and TNF-α levels had increased in infants later treated for ROP (p<0.05). Postnatal, infants treated for ROP had higher IL-6 levels than infants without ROP.

Conclusions: The pro-inflammatory response is associated with low IGF-I levels and the development of ROP.

Citing Articles

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