The 11q-Gain/Loss Aberration Occurs Recurrently in MYC-Negative Burkitt-like Lymphoma With 11q Aberration, As Well As MYC-Positive Burkitt Lymphoma and MYC-Positive High-Grade B-Cell Lymphoma, NOS

Overview

Journal Am J Clin Pathol

Publisher Oxford University Press

Specialty Pathology

Date 2017 Dec 23

PMID 29272887

Citations 20

Authors

Beata Grygalewicz

Renata Woroniecka

Grzegorz Rymkiewicz

Jolanta Rygier

Klaudia Borkowska

Aleksandra Kotyl

Katarzyna Blachnio

Zbigniew Bystydzienski

Beata Nowakowska

Barbara Pienkowska-Grela

Affiliations

Soon will be listed here.

Abstract

Objectives: The latest revision of lymphoma's World Health Organization classification describes the new provisional entity "Burkitt-like lymphoma with 11q aberration" (BLL, 11q) as lacking MYC rearrangement, but harboring the specific11q-gain/loss aberration. We report genetic characteristics of 11 lymphoma cases with this aberration.

Methods: Classical cytogenetics, fluorescence in situ hybridization (FISH), and single nucleotide polymorphism/array comparative genomic hybridization.

Results: The 11q aberrations were described as duplication, inversion, and deletion. Array comparative genomic hybridization showed two types of duplication: bigger than 50 megabase pairs (Mbp) and smaller than 20 Mbp, which were associated with bulky tumor larger than 20 cm and amplification of the 11q23.3 region, including KMT2A. Six cases revealed a normal FISH status of MYC and were diagnosed as BLL,11q. Five cases showed MYC rearrangement and were diagnosed as Burkitt lymphoma (BL) or high-grade B-cell lymphoma, not otherwise specified (HGBL, NOS).

Conclusions: The 11q-gain/loss is not specific for BLL, 11q, but occurs recurrently in MYC-positive BL and MYC-positive HGBL.

Citing Articles

microRNA Profile of High-Grade B-Cell Lymphoma with 11q Aberration.

Zajdel M, Szafron L, Paziewska A, Rymkiewicz G, Dabrowska M, Bystydzienski Z Int J Mol Sci. 2025; 26(1.

PMID: 39796140 PMC: 11720131. DOI: 10.3390/ijms26010285.

MYC-rearranged mature B-cell lymphomas in children and young adults are molecularly Burkitt Lymphoma.

Mato S, Castrejon-de-Anta N, Colmenero A, Carita L, Salmeron-Villalobos J, Ramis-Zaldivar J Blood Cancer J. 2024; 14(1):171.

PMID: 39375391 PMC: 11458770. DOI: 10.1038/s41408-024-01153-0.

High-grade B-cell lymphoma with 11q aberration in the HIV setting: a clinicopathological study of 10 cases and literature review.

Chang J, Liang Y, Gao Y, Wu M, Lv F, Liu H Infect Agent Cancer. 2024; 19(1):42.

PMID: 39261841 PMC: 11391791. DOI: 10.1186/s13027-024-00604-4.

[Clinical study of mature B-cell lymphoma in 11 children with chromosome 11 long-arm abnormalities].

Zhang N, Duan Y, Zhou C, Jin L, Yang J, Huang S Zhonghua Xue Ye Xue Za Zhi. 2024; 44(11):924-929.

PMID: 38185522 PMC: 10753258. DOI: 10.3760/cma.j.issn.0253-2727.2023.11.007.

Cytogenomic features of Richter transformation.

Woroniecka R, Rymkiewicz G, Bystydzienski Z, Pienkowska-Grela B, Rygier J, Malawska N Mol Cytogenet. 2023; 16(1):31.

PMID: 37941034 PMC: 10631075. DOI: 10.1186/s13039-023-00662-0.

References

Schmitz R, Young R, Ceribelli M, Jhavar S, Xiao W, Zhang M . Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics. Nature. 2012; 490(7418):116-20. PMC: 3609867. DOI: 10.1038/nature11378. View

Zhang X, Moussa O, LaRue A, Bradshaw S, Molano I, Spyropoulos D . The transcription factor Fli-1 modulates marginal zone and follicular B cell development in mice. J Immunol. 2008; 181(3):1644-54. PMC: 2504761. DOI: 10.4049/jimmunol.181.3.1644. View

Swerdlow S, Campo E, Pileri S, Lee Harris N, Stein H, Siebert R . The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016; 127(20):2375-90. PMC: 4874220. DOI: 10.1182/blood-2016-01-643569. View

Ferreiro J, Morscio J, Dierickx D, Marcelis L, Verhoef G, Vandenberghe P . Post-transplant molecularly defined Burkitt lymphomas are frequently MYC-negative and characterized by the 11q-gain/loss pattern. Haematologica. 2015; 100(7):e275-9. PMC: 4486241. DOI: 10.3324/haematol.2015.124305. View

Testoni M, Chung E, Priebe V, Bertoni F . The transcription factor ETS1 in lymphomas: friend or foe?. Leuk Lymphoma. 2014; 56(7):1975-80. DOI: 10.3109/10428194.2014.981670. View

Bonetti P, Testoni M, Scandurra M, Ponzoni M, Piva R, Mensah A . Deregulation of ETS1 and FLI1 contributes to the pathogenesis of diffuse large B-cell lymphoma. Blood. 2013; 122(13):2233-41. DOI: 10.1182/blood-2013-01-475772. View

Nielaender I, Martin-Subero J, Wagner F, Martinez-Climent J, Siebert R . Partial uniparental disomy: a recurrent genetic mechanism alternative to chromosomal deletion in malignant lymphoma. Leukemia. 2006; 20(5):904-5. DOI: 10.1038/sj.leu.2404173. View

Gondek L, Tiu R, OKeefe C, Sekeres M, Theil K, Maciejewski J . Chromosomal lesions and uniparental disomy detected by SNP arrays in MDS, MDS/MPD, and MDS-derived AML. Blood. 2007; 111(3):1534-42. PMC: 2214746. DOI: 10.1182/blood-2007-05-092304. View

Pienkowska-Grela B, Rymkiewicz G, Grygalewicz B, Woroniecka R, Krawczyk P, Czyz-Domanska K . Partial trisomy 11, dup(11)(q23q13), as a defect characterizing lymphomas with Burkitt pathomorphology without MYC gene rearrangement. Med Oncol. 2010; 28(4):1589-95. DOI: 10.1007/s12032-010-9614-0. View

10.

Zajdel M, Rymkiewicz G, Chechlinska M, Blachnio K, Pienkowska-Grela B, Grygalewicz B . miR expression in MYC-negative DLBCL/BL with partial trisomy 11 is similar to classical Burkitt lymphoma and different from diffuse large B-cell lymphoma. Tumour Biol. 2015; 36(7):5377-88. DOI: 10.1007/s13277-015-3203-y. View

11.

Salaverria I, Martin-Guerrero I, Wagener R, Kreuz M, Kohler C, Richter J . A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma. Blood. 2014; 123(8):1187-98. PMC: 3931189. DOI: 10.1182/blood-2013-06-507996. View

12.

Makishima H, Maciejewski J . Pathogenesis and consequences of uniparental disomy in cancer. Clin Cancer Res. 2011; 17(12):3913-23. PMC: 3523887. DOI: 10.1158/1078-0432.CCR-10-2900. View

13.

Sund K, Zimmerman S, Thomas C, Mitchell A, Prada C, Grote L . Regions of homozygosity identified by SNP microarray analysis aid in the diagnosis of autosomal recessive disease and incidentally detect parental blood relationships. Genet Med. 2012; 15(1):70-8. DOI: 10.1038/gim.2012.94. View

14.

Grygalewicz B, Woroniecka R, Rygier J, Borkowska K, Rzepecka I, Lukasik M . Monoallelic and biallelic deletions of 13q14 in a group of CLL/SLL patients investigated by CGH Haematological Cancer and SNP array (8x60K). Mol Cytogenet. 2016; 9:1. PMC: 4702365. DOI: 10.1186/s13039-015-0212-x. View

15.

Havelange V, Ameye G, Theate I, Callet-Bauchu E, Lippert E, Luquet I . The peculiar 11q-gain/loss aberration reported in a subset of MYC-negative high-grade B-cell lymphomas can also occur in a MYC-rearranged lymphoma. Cancer Genet. 2016; 209(3):117-8. DOI: 10.1016/j.cancergen.2015.12.005. View

16.

Morin R, Mendez-Lago M, Mungall A, Goya R, Mungall K, Corbett R . Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature. 2011; 476(7360):298-303. PMC: 3210554. DOI: 10.1038/nature10351. View

17.

OShea D, ORiain C, Gupta M, Waters R, Yang Y, Wrench D . Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation. Blood. 2009; 113(10):2298-301. PMC: 2652373. DOI: 10.1182/blood-2008-08-174953. View

18.

Hermetz K, Newman S, Conneely K, Martin C, Ballif B, Shaffer L . Large inverted duplications in the human genome form via a fold-back mechanism. PLoS Genet. 2014; 10(1):e1004139. PMC: 3907307. DOI: 10.1371/journal.pgen.1004139. View