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Liver-specific Deficiency of Unc-51 Like Kinase 1 and 2 Protects Mice from Acetaminophen-induced Liver Injury

Overview
Journal Hepatology
Specialty Gastroenterology
Date 2017 Dec 23
PMID 29272037
Citations 21
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Abstract

Conclusion: Together, these findings reveal an important role of Ulk1/2 for APAP-induced JNK activation and liver injury, and understanding of this regulatory mechanism may offer us new strategies for prevention and treatment of human APAP hepatotoxicity. (Hepatology 2018;67:2397-2413).

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