Alternative Polyadenylation in Human Diseases

Overview

Journal Endocrinol Metab (Seoul)

Specialty Endocrinology

Date 2017 Dec 23

PMID 29271615

Citations 20

Authors

Jae Woong Chang

Hsin Sung Yeh

Jeongsik Yong

Affiliations

Soon will be listed here.

Abstract

Varying length of messenger RNA (mRNA) 3'-untranslated region is generated by alternating the usage of polyadenylation sites during pre-mRNA processing. It is prevalent through all eukaryotes and has emerged as a key mechanism for controlling gene expression. Alternative polyadenylation (APA) plays an important role for cell growth, proliferation, and differentiation. In this review, we discuss the functions of APA related with various physiological conditions including cellular metabolism, mRNA processing, and protein diversity in a variety of disease models. We also discuss the molecular mechanisms underlying APA regulation, such as variations in the concentration of mRNA processing factors and RNA-binding proteins, as well as global transcriptome changes under cellular signaling pathway.

Citing Articles

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