Bacterial Nanocellulose Loaded with Bromelain: Assessment of Antimicrobial, Antioxidant and Physical-Chemical Properties

Overview

Journal Sci Rep

Specialty Science

Date 2017 Dec 23

PMID 29269741

Citations 20

Authors

Janaina Artem Ataide

Nathalia Mendes de Carvalho

Marcia de Araujo Rebelo

Marco Vinicius Chaud

Denise Grotto

Marli Gerenutti

Mahendra Rai

Priscila Gava Mazzola

Angela Faustino Jozala

Affiliations

Soon will be listed here.

Abstract

Bacterial nanocellulose (BNC) has desirable properties for wound healing such as high purity, good shape retention, and high water binding capacity. Bromelain is a protease found in pineapple tissues and has been applied in several fields, it has anti-inflammatory and anticancer properties, promotes cell apoptosis, amongst others. In this work, a BNC based device for the controlled release of bromelain was developed. BNC were submersed in sterilized bromelain solution and incubated at 25 °C under 100 rpm for 24 h. Physical-chemical properties, protein concentration, antioxidant and antimicrobial activities were measured. Results demonstrate that BNC could improve bromelain antimicrobial activity 9 times. Those findings allow concluding that bromelain is a promising molecule to be incorporated into BNC's. The BNC's characteristics seem to represent a new promising delivery system of the loaded biomolecule, and protected from external actions.

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