Effect of Vitamin D on Thyroid Autoimmunity: A Randomized, Double-Blind, Controlled Trial Among Ethnic Minorities

Overview

Journal J Endocr Soc

Specialty Endocrinology

Date 2017 Dec 22

PMID 29264502

Citations 12

Authors

Kirsten V Knutsen

Ahmed A Madar

Mette Brekke

Haakon E Meyer

Ase Ruth Eggemoen

Ibrahimu Mdala

Per Lagerlov

Affiliations

Soon will be listed here.

Abstract

Context: Autoimmune thyroid disorders have been linked to vitamin D deficiency, but an effect of vitamin D supplementation is not established.

Objective: Our objective was to test whether vitamin D compared with placebo could reduce thyroid autoantibodies.

Design: Predefined additional analyses from a randomized, double-blind, placebo-controlled trial.

Setting: The study was conducted in different community centers in Oslo, Norway.

Participants: A total of 251 presumed healthy men and women, aged 18 to 50 years, with backgrounds from South Asia, the Middle East, and Africa were included.

Intervention: Daily supplementation with 25 µg (1000 IU) vitamin D, 10 µg (400 IU) vitamin D, or placebo for 16 weeks.

Outcome Measure: Difference in preintervention and postintervention antithyroid peroxidase antibody (TPOAb) levels. Additional outcomes were differences in thyroid-stimulating hormone (TSH) and free fraction of thyroxine (fT4).

Results: There were no differences in change after 16 weeks on TPOAb (27 kU/L; 95% CI, -17 to 72; = 0.23), TSH (-0.10 mU/L; 95% CI, -0.54 to 0.34; = 0.65), or fT4 (0.09 pmol/L; 95% CI, -0.37 to 0.55; = 0.70) between those receiving vitamin D supplementation or placebo. Mean serum 25(OH)D increased from 26 to 49 nmol/L in the combined supplementation group, but there was no change in the placebo group.

Conclusion: Vitamin D supplementation, 25 µg or 10 µg, for 16 weeks compared with placebo did not affect TPOAb level in this randomized, double-blind study among participants with backgrounds from South Asia, the Middle East, and Africa who had low vitamin D levels at baseline.

Citing Articles

Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets.

Wang C, Chen Y, Yang B, Yang J, Wang W, Zeng Y Front Immunol. 2025; 16:1528707.

PMID: 39949783 PMC: 11821646. DOI: 10.3389/fimmu.2025.1528707.

Autoimmune Thyroiditis and Vitamin D.

Dura-Trave T, Gallinas-Victoriano F Int J Mol Sci. 2024; 25(6).

PMID: 38542128 PMC: 10969999. DOI: 10.3390/ijms25063154.

How Does Vitamin D Affect Immune Cells Crosstalk in Autoimmune Diseases?.

Gallo D, Baci D, Kustrimovic N, Lanzo N, Patera B, Tanda M Int J Mol Sci. 2023; 24(5).

PMID: 36902117 PMC: 10003699. DOI: 10.3390/ijms24054689.

Assessment of the reporting quality of randomised controlled trials for vitamin D supplementation in autoimmune thyroid disorders based on the CONSORT statement.

Vrysis C, Beneki E, Zintzaras E, Doxani C Endocrine. 2022; 80(2):346-354.

PMID: 36462148 PMC: 9735118. DOI: 10.1007/s12020-022-03270-x.

VITAMIN D LEVEL AND ITS RELATIONSHIP WITH CANCER STAGE IN PATIENTS WITH DIFFERENTIATED THYROID CARCINOMA.

Cocolos A, Vladoiu S, Caragheorgheopol A, Ghemigian A, Ioachim D, Poiana C Acta Endocrinol (Buchar). 2022; 18(2):168-173.

PMID: 36212258 PMC: 9512384. DOI: 10.4183/aeb.2022.168.

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