Blood Biomarkers and Gastric Cancer Survival in China

Infection with is the leading risk factor for noncardia gastric cancer, yet its influence on prognosis of gastric cancer is largely unknown. Thus, exploring the role of () in survival could lead to a greater understanding of the high mortality associated with gastric cancer. Seropositivity to 15 antigens was assessed using a multiplex assay in two prospective cohorts, the Shanghai Men's Health Study and the Shanghai Women's Health Study. Multivariable-adjusted Cox proportional hazards regression was used to examine the association between prediagnostic antigen levels and gastric cancer-specific survival. Prediagnostic levels of serum antibodies that were previously associated with gastric cancer incidence in this population were not associated with gastric cancer survival, whether assessed in a 6-antigen panel [HR = 1.29; 95% confidence interval (CI), 0.78-2.13 for men; HR = 0.93; 95% CI, 0.57-1.52 for women], focused on CagA (HR = 0.73; 95% CI, 0.44-1.20 forwomen; HR = 1.27; 95% CI, 0.70-2.31 for men) or on the high-risk biomarkers of dual Omp and HP 0305 seropositivity (HR = 0.97; 95% CI, 0.72-1.30 for women; HR = 1.37; 95% CI, 0.97-1.94 for men). Prediagnostic antigen levels are not associated with gastric cancer survival in East Asian populations. Identification of additional factors associated with gastric cancer survival would further our understanding of the high mortality associated with this malignancy. .