Genome Editing: Past, Present, and Future

Overview

Journal Yale J Biol Med

Specialty Biology

Date 2017 Dec 21

PMID 29259529

Citations 44

Authors

Dana Carroll

Affiliations

Soon will be listed here.

Abstract

The CRISPR-Cas genome editing tools have been adopted rapidly in the research community, and they are quickly finding applications in the commercial sector as well. Lest we lose track of the broader context, this Perspective presents a brief review of the history of the genome editing platforms and considers a few current technological issues. It then takes a very limited view into the future of this technology and highlights some of the societal issues that require examination and discussion.

Citing Articles

CRISPR-Based Editing of the Gene.

Potsenkovskaia E, Tvorogova V, Simonova V, Konstantinov Z, Kiseleva A, Matveenko A Plants (Basel). 2024; 13(22).

PMID: 39599434 PMC: 11598548. DOI: 10.3390/plants13223226.

Therapeutic Gene Editing in Dyslipidemias.

Tamehri Zadeh S, Shapiro M Rev Cardiovasc Med. 2024; 25(8):286.

PMID: 39228490 PMC: 11367006. DOI: 10.31083/j.rcm2508286.

Advancing crop disease resistance through genome editing: a promising approach for enhancing agricultural production.

Manzoor S, Nabi S, Rather T, Gani G, Mir Z, Wani A Front Genome Ed. 2024; 6:1399051.

PMID: 38988891 PMC: 11234172. DOI: 10.3389/fgeed.2024.1399051.

Gene editing in small and large animals for translational medicine: a review.

Mariano C, de Oliveira V, Ambrosio C Anim Reprod. 2024; 21(1):e20230089.

PMID: 38628493 PMC: 11019828. DOI: 10.1590/1984-3143-AR2023-0089.

Harnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor loci.

Zhang X, Van Treeck B, Horton C, McIntyre J, Palm S, Shumate J Nat Biotechnol. 2024; 43(1):42-51.

PMID: 38379101 PMC: 11371274. DOI: 10.1038/s41587-024-02137-y.

References

Beumer K, Trautman J, Bozas A, Liu J, Rutter J, Gall J . Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases. Proc Natl Acad Sci U S A. 2008; 105(50):19821-6. PMC: 2604940. DOI: 10.1073/pnas.0810475105. View

Chu V, Weber T, Wefers B, Wurst W, Sander S, Rajewsky K . Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells. Nat Biotechnol. 2015; 33(5):543-8. DOI: 10.1038/nbt.3198. View

Gaj T, Gersbach C, Barbas 3rd C . ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends Biotechnol. 2013; 31(7):397-405. PMC: 3694601. DOI: 10.1016/j.tibtech.2013.04.004. View

Gantz V, Jasinskiene N, Tatarenkova O, Fazekas A, Macias V, Bier E . Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi. Proc Natl Acad Sci U S A. 2015; 112(49):E6736-43. PMC: 4679060. DOI: 10.1073/pnas.1521077112. View

Maruyama T, Dougan S, Truttmann M, Bilate A, Ingram J, Ploegh H . Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining. Nat Biotechnol. 2015; 33(5):538-42. PMC: 4618510. DOI: 10.1038/nbt.3190. View

Pabo C, Peisach E, Grant R . Design and selection of novel Cys2His2 zinc finger proteins. Annu Rev Biochem. 2001; 70:313-40. DOI: 10.1146/annurev.biochem.70.1.313. View

Barrangou R, Marraffini L . CRISPR-Cas systems: Prokaryotes upgrade to adaptive immunity. Mol Cell. 2014; 54(2):234-44. PMC: 4025954. DOI: 10.1016/j.molcel.2014.03.011. View

Boch J, Scholze H, Schornack S, Landgraf A, Hahn S, Kay S . Breaking the code of DNA binding specificity of TAL-type III effectors. Science. 2009; 326(5959):1509-12. DOI: 10.1126/science.1178811. View

Lee K, Mackley V, Rao A, Chong A, DeWitt M, Corn J . Synthetically modified guide RNA and donor DNA are a versatile platform for CRISPR-Cas9 engineering. Elife. 2017; 6. PMC: 5413346. DOI: 10.7554/eLife.25312. View

10.

Tebas P, Stein D, Tang W, Frank I, Wang S, Lee G . Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. N Engl J Med. 2014; 370(10):901-10. PMC: 4084652. DOI: 10.1056/NEJMoa1300662. View

11.

Menger L, Sledzinska A, Bergerhoff K, Vargas F, Smith J, Poirot L . TALEN-Mediated Inactivation of PD-1 in Tumor-Reactive Lymphocytes Promotes Intratumoral T-cell Persistence and Rejection of Established Tumors. Cancer Res. 2016; 76(8):2087-93. DOI: 10.1158/0008-5472.CAN-15-3352. View

12.

Clasen B, Stoddard T, Luo S, Demorest Z, Li J, Cedrone F . Improving cold storage and processing traits in potato through targeted gene knockout. Plant Biotechnol J. 2015; 14(1):169-76. PMC: 11389148. DOI: 10.1111/pbi.12370. View

13.

Chin J, Glazer P . Repair of DNA lesions associated with triplex-forming oligonucleotides. Mol Carcinog. 2008; 48(4):389-99. PMC: 2745299. DOI: 10.1002/mc.20501. View

14.

Proudfoot C, Carlson D, Huddart R, Long C, Pryor J, King T . Genome edited sheep and cattle. Transgenic Res. 2014; 24(1):147-53. PMC: 4274373. DOI: 10.1007/s11248-014-9832-x. View

15.

Bozas A, Beumer K, Trautman J, Carroll D . Genetic analysis of zinc-finger nuclease-induced gene targeting in Drosophila. Genetics. 2009; 182(3):641-51. PMC: 2710147. DOI: 10.1534/genetics.109.101329. View

16.

Hess G, Fresard L, Han K, Lee C, Li A, Cimprich K . Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells. Nat Methods. 2016; 13(12):1036-1042. PMC: 5557288. DOI: 10.1038/nmeth.4038. View

17.

Cyranoski D . Chinese scientists to pioneer first human CRISPR trial. Nature. 2016; 535(7613):476-7. DOI: 10.1038/nature.2016.20302. View

18.

Carlson D, Lancto C, Zang B, Kim E, Walton M, Oldeschulte D . Production of hornless dairy cattle from genome-edited cell lines. Nat Biotechnol. 2016; 34(5):479-81. DOI: 10.1038/nbt.3560. View

19.

Akbari O, Bellen H, Bier E, Bullock S, Burt A, Church G . BIOSAFETY. Safeguarding gene drive experiments in the laboratory. Science. 2015; 349(6251):927-9. PMC: 4692367. DOI: 10.1126/science.aac7932. View

20.

LATT S . Sister chromatid exchange formation. Annu Rev Genet. 1981; 15:11-55. DOI: 10.1146/annurev.ge.15.120181.000303. View