Molecular and Cellular Events Involved in the Completion of Blastocyst Implantation

Overview

Journal Reprod Med Biol

Specialty Biology

Date 2017 Dec 21

PMID 29259421

Citations 9

Authors

Hiromichi Matsumoto

Emiko Fukui

Midori Yoshizawa

Affiliations

Soon will be listed here.

Abstract

Blastocyst implantation is an interactive process between the embryo and the uterus. The synchronization of embryonic development with uterine differentiation to a receptive state is essential for a successful pregnancy. The period of uterine receptivity for implantation is limited. Although implantation involves the interaction of numerous signaling molecules, our understanding of the hierarchical mechanisms that coordinate with the embryo-uterine dialogue is not yet sufficient to prevent infertility caused by implantation failure. This review highlights our knowledge on uterine receptivity and hormonal regulation of blastocyst implantation in mice. We also discuss the adhesion molecules, cross-linker proteins, extracellular proteins, and matricellular proteins involved in blastocyst implantation. Furthermore, our recent study reveals that selective proteolysis in an activated blastocyst is associated with the completion of blastocyst implantation after embryo transfer. A better understanding of uterine and blastocyst biology during the peri-implantation period would facilitate further development of reproductive technology.

Citing Articles

Molecular and cellular regulators of embryo implantation and their application in improving the implantation potential of IVF-derived blastocysts.

Liu C, Fukui E, Matsumoto H Reprod Med Biol. 2025; 24(1):e12633.

PMID: 39866379 PMC: 11759885. DOI: 10.1002/rmb2.12633.

Spatiotemporally distinct roles of cyclooxygenase-1 and cyclooxygenase-2 at fetomaternal interface in mice.

Aikawa S, Matsuo M, Akaeda S, Sugimoto Y, Arita M, Isobe Y JCI Insight. 2024; 9(19).

PMID: 39377223 PMC: 11466189. DOI: 10.1172/jci.insight.181865.

Arginine with leucine drives reactive oxygen species-mediated integrin α5β1 expression and promotes implantation in mouse blastocysts.

Nakazato M, Matsuzaki M, Okai D, Takeuchi E, Seki M, Takeuchi M PNAS Nexus. 2024; 3(3):pgae114.

PMID: 38525303 PMC: 10959068. DOI: 10.1093/pnasnexus/pgae114.

Upregulation of iNOS and phosphorylated eNOS in the implantation-induced blastocysts of mice.

Seki M, Takeuchi E, Fukui E, Matsumoto H Reprod Med Biol. 2023; 22(1):e12545.

PMID: 37841392 PMC: 10568119. DOI: 10.1002/rmb2.12545.

Early Progesterone Change Associated With Pregnancy Outcome After Fresh Embryo Transfer in Assisted Reproduction Technology Cycles With Progesterone Level of >1.5 ng/ml on Human Chorionic Gonadotropin Trigger Day.

Lee C, Chen H, Huang C, Lin P, Lee T, Lee M Front Endocrinol (Lausanne). 2020; 11:653.

PMID: 33042015 PMC: 7522275. DOI: 10.3389/fendo.2020.00653.

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