Diagnostic Importance of Hyphae on Heart Valve Tissue in Histoplasma Endocarditis and Treatment With Isavuconazole

Overview

Journal Open Forum Infect Dis

Specialty Infectious Diseases

Date 2017 Dec 20

PMID 29255737

Citations 6

Authors

Zanthia Wiley

Michael H Woodworth

Jesse T Jacob

Shawn R Lockhart

Nadine G Rouphael

Jonathan C Gullett

Jeannette Guarner

Kimberly Workowski

Affiliations

Soon will be listed here.

Abstract

A patient who never resided in an endemic area for dimorphic fungi was diagnosed with endocarditis. His diagnosis was suggested by yeast and hyphae on cardiac valve tissue pathology. Isavuconazole was an optimal therapeutic option due to renal dysfunction and anticoagulation with warfarin for mechanical valve replacement.

Citing Articles

Disseminated histoplasmosis in an immunosuppressed patient successfully treated with isavuconazole.

Sircar A, Tran M, Vaidya S, Goldstein E, Wheat L BMJ Case Rep. 2023; 16(8).

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New Perspectives on Antimicrobial Agents: Isavuconazole.

Lewis 2nd J, Wiederhold N, Hakki M, Thompson 3rd G Antimicrob Agents Chemother. 2022; 66(9):e0017722.

PMID: 35969068 PMC: 9487460. DOI: 10.1128/aac.00177-22.

Rare case of endocarditis in a patient with a prosthetic valve.

Manning E, Zorach B, Kumar A Eur Heart J Case Rep. 2022; 6(3):ytac086.

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Native vs Prosthetic Valve Infective Endocarditis: A Case Report and Systemic Literature Review Comparing Patient Presentation, Treatment Modalities, Clinical Outcomes, and Diagnostic Laboratory Testing.

Boyanton Jr B, Boamah H, Lauter C Open Forum Infect Dis. 2021; 8(8):ofab360.

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Isavuconazole-Animal Data and Clinical Data.

Pagano L, Cattaneo C, Quattrone M, Oberti M, Mazzitelli M, Trecarichi E J Fungi (Basel). 2020; 6(4).

PMID: 33036295 PMC: 7712195. DOI: 10.3390/jof6040209.

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