Natural History of COPD: Gaps and Opportunities

Overview

Journal ERJ Open Res

Specialty Pulmonary Medicine

Date 2017 Dec 20

PMID 29255718

Citations 22

Authors

Alvar Agusti

Bartolome Celli

Affiliations

Soon will be listed here.

Abstract

Understanding the natural history of a disease is as important as knowing its cause(s) for effective disease prevention and treatment. Yet, our current understanding of the natural history of chronic obstructive pulmonary disease (COPD) is incomplete and often controversial. This article discusses the current gaps, and hence opportunities for research, in this field. In particular, it discusses the following six specific questions. 1) Is COPD a "single" disease? 2) Is COPD "only" a lung disease? 3) When does COPD begin or what is "early" COPD? 4) How does COPD "progress"? 5) How do we assess disease "severity"? 6) Can COPD be prevented (beyond smoking cessation) or its course be modified once detected?

Citing Articles

Twenty years of changes in the definition of early chronic obstructive pulmonary disease.

Chen D, Curtis J, Chen Y Chin Med J Pulm Crit Care Med. 2024; 1(2):84-93.

PMID: 39170827 PMC: 11332824. DOI: 10.1016/j.pccm.2023.03.004.

Blood eosinophils levels in a Colombian cohort of biomass-and tobacco-related COPD patients.

Garcia Morales O, Canas-Arboleda A, Rodriguez Malagon M, Galindo Pedraza J, Rodriguez Torres P, Avendano Morales V Front Med (Lausanne). 2024; 11:1321371.

PMID: 38803343 PMC: 11128574. DOI: 10.3389/fmed.2024.1321371.

Mechanisms of lung damage in tuberculosis: implications for chronic obstructive pulmonary disease.

Kayongo A, Nyiro B, Siddharthan T, Kirenga B, Checkley W, Joloba M Front Cell Infect Microbiol. 2023; 13:1146571.

PMID: 37415827 PMC: 10320222. DOI: 10.3389/fcimb.2023.1146571.

Air pollution as an early determinant of COPD.

Lu Z, Coll P, Maitre B, Epaud R, Lanone S Eur Respir Rev. 2022; 31(165).

PMID: 35948393 PMC: 9724895. DOI: 10.1183/16000617.0059-2022.

Definition and Nomenclature of Chronic Obstructive Pulmonary Disease: Time for Its Revision.

Celli B, Fabbri L, Criner G, Martinez F, Mannino D, Vogelmeier C Am J Respir Crit Care Med. 2022; 206(11):1317-1325.

PMID: 35914087 PMC: 9746870. DOI: 10.1164/rccm.202204-0671PP.

References

Celli B, Tetzlaff K, Criner G, Polkey M, Sciurba F, Casaburi R . The 6-Minute-Walk Distance Test as a Chronic Obstructive Pulmonary Disease Stratification Tool. Insights from the COPD Biomarker Qualification Consortium. Am J Respir Crit Care Med. 2016; 194(12):1483-1493. PMC: 5215028. DOI: 10.1164/rccm.201508-1653OC. View

Cote C, Celli B . Pulmonary rehabilitation and the BODE index in COPD. Eur Respir J. 2005; 26(4):630-6. DOI: 10.1183/09031936.05.00045505. View

Rennard S, Drummond M . Early chronic obstructive pulmonary disease: definition, assessment, and prevention. Lancet. 2015; 385(9979):1778-1788. PMC: 4819246. DOI: 10.1016/S0140-6736(15)60647-X. View

Martinez F . Early-Life Origins of Chronic Obstructive Pulmonary Disease. N Engl J Med. 2016; 375(9):871-8. DOI: 10.1056/NEJMra1603287. View

Guirguis-Blake J, Senger C, Webber E, Mularski R, Whitlock E . Screening for Chronic Obstructive Pulmonary Disease: Evidence Report and Systematic Review for the US Preventive Services Task Force. JAMA. 2016; 315(13):1378-93. DOI: 10.1001/jama.2016.2654. View

Kim W, Silverman E, Hoffman E, Criner G, Mosenifar Z, Sciurba F . CT metrics of airway disease and emphysema in severe COPD. Chest. 2009; 136(2):396-404. PMC: 2733947. DOI: 10.1378/chest.08-2858. View

Rodriguez-Roisin R, Han M, Vestbo J, Wedzicha J, Woodruff P, Martinez F . Chronic Respiratory Symptoms with Normal Spirometry. A Reliable Clinical Entity?. Am J Respir Crit Care Med. 2016; 195(1):17-22. DOI: 10.1164/rccm.201607-1376PP. View

Sin D, Anthonisen N, Soriano J, Agusti A . Mortality in COPD: Role of comorbidities. Eur Respir J. 2006; 28(6):1245-57. DOI: 10.1183/09031936.00133805. View

Bush A . Lung Development and Aging. Ann Am Thorac Soc. 2016; 13 Suppl 5:S438-S446. DOI: 10.1513/AnnalsATS.201602-112AW. View

10.

Celermajer D, Sorensen K, Gooch V, Spiegelhalter D, Miller O, Sullivan I . Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 1992; 340(8828):1111-5. DOI: 10.1016/0140-6736(92)93147-f. View

11.

Puente-Maestu L, Palange P, Casaburi R, Laveneziana P, Maltais F, Neder J . Use of exercise testing in the evaluation of interventional efficacy: an official ERS statement. Eur Respir J. 2016; 47(2):429-60. DOI: 10.1183/13993003.00745-2015. View

12.

Decramer M, Cooper C . Treatment of COPD: the sooner the better?. Thorax. 2010; 65(9):837-41. DOI: 10.1136/thx.2009.133355. View

13.

Barnes P, Chowdhury B, Kharitonov S, Magnussen H, Page C, Postma D . Pulmonary biomarkers in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2006; 174(1):6-14. DOI: 10.1164/rccm.200510-1659PP. View

14.

Barker D, Godfrey K, Fall C, Osmond C, WINTER P, Shaheen S . Relation of birth weight and childhood respiratory infection to adult lung function and death from chronic obstructive airways disease. BMJ. 1991; 303(6804):671-5. PMC: 1670943. DOI: 10.1136/bmj.303.6804.671. View

15.

Fabbri L, Luppi F, Beghe B, Rabe K . Complex chronic comorbidities of COPD. Eur Respir J. 2008; 31(1):204-12. DOI: 10.1183/09031936.00114307. View

16.

Alcaide A, Sanchez-Salcedo P, Bastarrika G, Campo A, Berto J, Ocon M . Clinical Features of Smokers With Radiological Emphysema But Without Airway Limitation. Chest. 2016; 151(2):358-365. DOI: 10.1016/j.chest.2016.10.044. View

17.

McCarthy B, Casey D, Devane D, Murphy K, Murphy E, Lacasse Y . Pulmonary rehabilitation for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2015; (2):CD003793. PMC: 10008021. DOI: 10.1002/14651858.CD003793.pub3. View

18.

Labaki W, Martinez C, Martinez F, Galban C, Ross B, Washko G . The Role of Chest Computed Tomography in the Evaluation and Management of the Patient with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2017; 196(11):1372-1379. PMC: 5736976. DOI: 10.1164/rccm.201703-0451PP. View

19.

Vogelmeier C, Criner G, Martinez F, Anzueto A, Barnes P, Bourbeau J . Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary. Eur Respir J. 2017; 49(3). DOI: 10.1183/13993003.00214-2017. View

20.

Bui D, Burgess J, Lowe A, Perret J, Lodge C, Bui M . Childhood Lung Function Predicts Adult Chronic Obstructive Pulmonary Disease and Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome. Am J Respir Crit Care Med. 2017; 196(1):39-46. DOI: 10.1164/rccm.201606-1272OC. View