Lipotoxicity Induces Hepatic Protein Inclusions Through TANK Binding Kinase 1-mediated P62/sequestosome 1 Phosphorylation

Overview

Journal Hepatology

Specialty Gastroenterology

Date 2017 Dec 19

PMID 29251796

Citations 58

Authors

Chun-Seok Cho

Hwan-Woo Park

Allison Ho

Ian A Semple

Boyoung Kim

Insook Jang

Haeli Park

Shannon Reilly

Alan R Saltiel

Jun Hee Lee

Affiliations

Soon will be listed here.

Abstract

Conclusion: These results suggest that lipotoxic activation of TBK1 and subsequent p62 phosphorylation are critical steps in the NASH pathology of protein inclusion accumulation in hepatocytes. This mechanism can provide an explanation for how hypernutrition and obesity promote the development of severe liver pathologies, such as steatohepatitis and liver cancer, by facilitating the formation of p62 inclusions. (Hepatology 2018).

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