Eosinophils Mediate Tissue Injury in the Autoimmune Skin Disease Bullous Pemphigoid

Overview

Journal J Invest Dermatol

Publisher Elsevier

Specialty Dermatology

Date 2017 Dec 17

PMID 29246800

Citations 43

Authors

Lan Lin

Bin-Jin Hwang

Donna A Culton

Ning Li

Susan Burette

Beverly H Koller

Kelly A Messingham

Janet A Fairley

James J Lee

Russell P Hall

Lijia An

Luis A Diaz

Zhi Liu

Affiliations

Soon will be listed here.

Abstract

Eosinophils are typically associated with unique inflammatory settings, including allergic inflammation and helminth infections. However, new information suggests that eosinophils contribute more broadly to inflammatory responses and participate in local immune regulation and the tissue remodeling/repair events linked with a variety of diseases. Eosinophilic infiltration has long been a histologic hallmark of bullous pemphigoid (BP), a subepidermal autoimmune blistering disease characterized by autoantibodies directed against basement membrane protein BP180. However, the exact role of eosinophils in disease pathogenesis remains largely unknown. We show here that eosinophils are necessary for IgE autoantibody-mediated BP blister formation in a humanized IgE receptor mouse model of BP. Disease severity is IgE dose dependent and correlates with the degree of eosinophil infiltration in the skin. Furthermore, IgE autoantibodies fail to induce BP in eosinophil-deficient mice, confirming that eosinophils are required for IgE-mediated tissue injury. Thus, eosinophils provide the cellular link between IgE autoantibodies and skin blistering in this murine model of BP. These findings suggest a role for eosinophils in autoimmune disease and have important implications for the treatment of BP and other antibody-mediated inflammatory and autoimmune diseases.

Citing Articles

Bullous pemphigoid.

Akbarialiabad H, Schmidt E, Patsatsi A, Lim Y, Mosam A, Tasanen K Nat Rev Dis Primers. 2025; 11(1):12.

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Associated factors related to production of autoantibodies and dermo-epidermal separation in bullous pemphigoid.

Yang L, Wang Y, Zuo Y Arch Dermatol Res. 2025; 317(1):303.

PMID: 39853516 DOI: 10.1007/s00403-024-03760-0.

Pathophysiology of Bullous Pemphigoid: Role of Type 2 Inflammation and Emerging Treatment Strategies (Narrative Review).

Werth V, Murrell D, Joly P, Heck R, Orengo J, Ardeleanu M Adv Ther. 2024; 41(12):4418-4432.

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Recent Applications of Amphiphilic Copolymers in Drug Release Systems for Skin Treatment.

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Helicobacter pylori infection an underestimated trigger of bullous pemphigoid?.

Abu Rached N, Stranzenbach R, Scholl L, Stockfleth E, Gambichler T J Dtsch Dermatol Ges. 2024; 23(1):97-99.

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