Cardiomyokines from the Heart

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2017 Dec 15

PMID 29238844

Citations 12

Authors

Ayano Chiba

Haruko Watanabe-Takano

Takahiro Miyazaki

Naoki Mochizuki

Affiliations

Soon will be listed here.

Abstract

The heart is regarded as an endocrine organ as well as a pump for circulation, since atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) were discovered in cardiomyocytes to be secreted as hormones. Both ANP and BNP bind to their receptors expressed on remote organs, such as kidneys and blood vessels; therefore, the heart controls the circulation by pumping blood and by secreting endocrine peptides. Cardiomyocytes secrete other peptides besides natriuretic peptides. Although most of such cardiomyocyte-derived peptides act on the heart in autocrine/paracrine fashions, several peptides target remote organs. In this review, to overview current knowledge of endocrine properties of the heart, we focus on cardiomyocyte-derived peptides (cardiomyokines) that act on the remote organs as well as the heart. Cardiomyokines act on remote organs to regulate cardiovascular homeostasis, systemic metabolism, and inflammation. Therefore, through its endocrine function, the heart can maintain physiological conditions and prevent organ damage under pathological conditions.

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References

Heineke J, Auger-Messier M, Xu J, Sargent M, York A, Welle S . Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure. Circulation. 2010; 121(3):419-25. PMC: 2823256. DOI: 10.1161/CIRCULATIONAHA.109.882068. View

Yamazaki T, Komuro I, Kudoh S, Zou Y, Shiojima I, Hiroi Y . Endothelin-1 is involved in mechanical stress-induced cardiomyocyte hypertrophy. J Biol Chem. 1996; 271(6):3221-8. DOI: 10.1074/jbc.271.6.3221. View

Moro C, Pasarica M, Elkind-Hirsch K, Redman L . Aerobic exercise training improves atrial natriuretic peptide and catecholamine-mediated lipolysis in obese women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2009; 94(7):2579-86. PMC: 5393377. DOI: 10.1210/jc.2009-0051. View

Patel V, Adya R, Chen J, Ramanjaneya M, Bari M, Bhudia S . Novel insights into the cardio-protective effects of FGF21 in lean and obese rat hearts. PLoS One. 2014; 9(2):e87102. PMC: 3911936. DOI: 10.1371/journal.pone.0087102. View

Engeli S, Birkenfeld A, Badin P, Bourlier V, Louche K, Viguerie N . Natriuretic peptides enhance the oxidative capacity of human skeletal muscle. J Clin Invest. 2012; 122(12):4675-9. PMC: 3533552. DOI: 10.1172/JCI64526. View

Tanaka M, Murakami K, Ozaki S, Imura Y, Tong X, Watanabe T . DIP2 disco-interacting protein 2 homolog A (Drosophila) is a candidate receptor for follistatin-related protein/follistatin-like 1--analysis of their binding with TGF-β superfamily proteins. FEBS J. 2010; 277(20):4278-89. DOI: 10.1111/j.1742-4658.2010.07816.x. View

Shohet R, Kisanuki Y, Zhao X, Siddiquee Z, Franco F, Yanagisawa M . Mice with cardiomyocyte-specific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy. Proc Natl Acad Sci U S A. 2004; 101(7):2088-93. PMC: 357056. DOI: 10.1073/pnas.0307159101. View

Chen Y . Atrial natriuretic peptide in hypoxia. Peptides. 2005; 26(6):1068-77. DOI: 10.1016/j.peptides.2004.08.030. View

Redondo J, Bishop J, Wilkins M . Effect of atrial natriuretic peptide and cyclic GMP phosphodiesterase inhibition on collagen synthesis by adult cardiac fibroblasts. Br J Pharmacol. 1998; 124(7):1455-62. PMC: 1565547. DOI: 10.1038/sj.bjp.0701994. View

10.

Nagaya N, Nishikimi T, Goto Y, Miyao Y, Kobayashi Y, Morii I . Plasma brain natriuretic peptide is a biochemical marker for the prediction of progressive ventricular remodeling after acute myocardial infarction. Am Heart J. 1998; 135(1):21-8. DOI: 10.1016/s0002-8703(98)70338-2. View

11.

Montgomery R, Hullinger T, Semus H, Dickinson B, Seto A, Lynch J . Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure. Circulation. 2011; 124(14):1537-47. PMC: 3353551. DOI: 10.1161/CIRCULATIONAHA.111.030932. View

12.

Flynn T, de Bold M, de Bold A . The amino acid sequence of an atrial peptide with potent diuretic and natriuretic properties. Biochem Biophys Res Commun. 1983; 117(3):859-65. DOI: 10.1016/0006-291x(83)91675-3. View

13.

Oshima Y, Ouchi N, Shimano M, Pimentel D, Papanicolaou K, Panse K . Activin A and follistatin-like 3 determine the susceptibility of heart to ischemic injury. Circulation. 2009; 120(16):1606-15. PMC: 2764796. DOI: 10.1161/CIRCULATIONAHA.109.872200. View

14.

Itoh N, Ohta H, Nakayama Y, Konishi M . Roles of FGF Signals in Heart Development, Health, and Disease. Front Cell Dev Biol. 2016; 4:110. PMC: 5067508. DOI: 10.3389/fcell.2016.00110. View

15.

Berry E, Hernandez-Anzaldo S, Ghomashchi F, Lehner R, Murakami M, Gelb M . Matrix metalloproteinase-2 negatively regulates cardiac secreted phospholipase A2 to modulate inflammation and fever. J Am Heart Assoc. 2015; 4(4). PMC: 4579961. DOI: 10.1161/JAHA.115.001868. View

16.

Schlueter N, de Sterke A, Willmes D, Spranger J, Jordan J, Birkenfeld A . Metabolic actions of natriuretic peptides and therapeutic potential in the metabolic syndrome. Pharmacol Ther. 2014; 144(1):12-27. DOI: 10.1016/j.pharmthera.2014.04.007. View

17.

Fleming J, STEINHAUSEN M . Atrial natriuretic peptide causes pre-glomerular vasodilatation and post-glomerular vasoconstriction in rat kidney. Nature. 1986; 324(6096):473-6. DOI: 10.1038/324473a0. View

18.

Fukuda Y, Hirata Y, Yoshimi H, Kojima T, Kobayashi Y, Yanagisawa M . Endothelin is a potent secretagogue for atrial natriuretic peptide in cultured rat atrial myocytes. Biochem Biophys Res Commun. 1988; 155(1):167-72. DOI: 10.1016/s0006-291x(88)81064-7. View

19.

Angelone T, Quintieri A, Brar B, Limchaiyawat P, Tota B, Mahata S . The antihypertensive chromogranin a peptide catestatin acts as a novel endocrine/paracrine modulator of cardiac inotropism and lusitropism. Endocrinology. 2008; 149(10):4780-93. PMC: 2582908. DOI: 10.1210/en.2008-0318. View

20.

Ge X, Chen C, Hui X, Wang Y, Lam K, Xu A . Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes. J Biol Chem. 2011; 286(40):34533-41. PMC: 3186365. DOI: 10.1074/jbc.M111.248591. View