Comparison of Dexmedetomidine and Fentanyl As Local Anesthetic Adjuvants in Spinal Anesthesia: a Systematic Review and Meta-analysis of Randomized Controlled Trials

Overview

Journal Drug Des Devel Ther

Specialty Pharmacology

Date 2017 Dec 15

PMID 29238167

Citations 30

Authors

Shujun Sun

Jiamei Wang

Naren Bao

Ying Chen

Jun Wang

Affiliations

Soon will be listed here.

Abstract

Purpose: To compare the effects of dexmedetomidine (Dex) and fentanyl as adjuvants to local anesthetics in spinal anesthesia.

Methods: Two researchers independently searched the PUBMED, EMBASE, Cochrane library, and CBM for randomized controlled trials comparing the effects of Dex and fentanyl as adjuvants to local anesthetics for intrathecal injection.

Results: A total of 639 patients from nine studies were included in this meta-analysis. The results showed that Dex resulted in statistically significant longer duration of stable sensory block (mean difference [MD] =27.12; 95% confidence interval [CI] [9.89, 44.34], <0.01, =97%), sensory block (standardized mean difference [SMD] =3.81; 95% CI [2.35, 5.27], <0.01, =97%), motor block (SMD =3.64; 95% CI [2.19, 5.08], <0.01, =97%), and pain free period (SMD =2.98; 95% CI [1.69, 4.27], <0.01, =96%); reducing the incidence of pruritus (relative risk [RR] =0.15; 95% CI [0.06, 0.39], <0.01, =0%) compared with fentanyl. However, the onset of sensory and motor block, the time to peak sensory level, and the incidence of hypotension and bradycardia, and the side effects (nausea, vomiting, shivering and respiratory depression) were not significantly different between Dex and fentanyl.

Conclusion: Compared to fentanyl, Dex as local anesthetics adjuvant in spinal anesthesia prolonged the duration of spinal anesthesia, improved postoperative analgesia, reduced the incidence of pruritus, and did not increase the incidence of hypotension and bradycardia.

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