Recent Advances in Marine Algae Polysaccharides: Isolation, Structure, and Activities

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2017 Dec 14

PMID 29236064

Citations 108

Authors

Shu-Ying Xu

Xuesong Huang

Kit-Leong Cheong

Affiliations

Soon will be listed here.

Abstract

Marine algae have attracted a great deal of interest as excellent sources of nutrients. Polysaccharides are the main components in marine algae, hence a great deal of attention has been directed at isolation and characterization of marine algae polysaccharides because of their numerous health benefits. In this review, extraction and purification approaches and chemico-physical properties of marine algae polysaccharides (MAPs) are summarized. The biological activities, which include immunomodulatory, antitumor, antiviral, antioxidant, and hypolipidemic, are also discussed. Additionally, structure-function relationships are analyzed and summarized. MAPs' biological activities are closely correlated with their monosaccharide composition, molecular weights, linkage types, and chain conformation. In order to promote further exploitation and utilization of polysaccharides from marine algae for functional food and pharmaceutical areas, high efficiency, and low-cost polysaccharide extraction and purification methods, quality control, structure-function activity relationships, and specific mechanisms of MAPs activation need to be extensively investigated.

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References

Kang Y, Li H, Wu J, Xu X, Sun X, Zhao X . Transcriptome Profiling Reveals the Antitumor Mechanism of Polysaccharide from Marine Algae Gracilariopsis lemaneiformis. PLoS One. 2016; 11(6):e0158279. PMC: 4927116. DOI: 10.1371/journal.pone.0158279. View

Patel A, Laroche C, Marcati A, Ursu A, Jubeau S, Marchal L . Separation and fractionation of exopolysaccharides from Porphyridium cruentum. Bioresour Technol. 2013; 145:345-50. DOI: 10.1016/j.biortech.2012.12.038. View

Youssouf L, Lallemand L, Giraud P, Soule F, Bhaw-Luximon A, Meilhac O . Ultrasound-assisted extraction and structural characterization by NMR of alginates and carrageenans from seaweeds. Carbohydr Polym. 2017; 166:55-63. DOI: 10.1016/j.carbpol.2017.01.041. View

Chen X, Nie W, Yu G, Li Y, Hu Y, Lu J . Antitumor and immunomodulatory activity of polysaccharides from Sargassum fusiforme. Food Chem Toxicol. 2011; 50(3-4):695-700. DOI: 10.1016/j.fct.2011.11.015. View

Yasuhara-Bell J, Lu Y . Marine compounds and their antiviral activities. Antiviral Res. 2010; 86(3):231-40. PMC: 7132374. DOI: 10.1016/j.antiviral.2010.03.009. View

Wang X, Zhang Z . The antitumor activity of a red alga polysaccharide complexes carrying 5-fluorouracil. Int J Biol Macromol. 2014; 69:542-5. DOI: 10.1016/j.ijbiomac.2014.06.017. View

Sousa W, Silva R, Bezerra F, Bingana R, Barros F, Costa L . Sulfated polysaccharide fraction from marine algae Solieria filiformis: Structural characterization, gastroprotective and antioxidant effects. Carbohydr Polym. 2016; 152:140-148. DOI: 10.1016/j.carbpol.2016.06.111. View

Zhang W, Oda T, Yu Q, Jin J . Fucoidan from Macrocystis pyrifera has powerful immune-modulatory effects compared to three other fucoidans. Mar Drugs. 2015; 13(3):1084-104. PMC: 4377974. DOI: 10.3390/md13031084. View

Rahman M, Halfar J . First evidence of chitin in calcified coralline algae: new insights into the calcification process of Clathromorphum compactum. Sci Rep. 2014; 4:6162. PMC: 4141250. DOI: 10.1038/srep06162. View

10.

de Jesus Raposo M, de Morais A, de Morais R . Marine polysaccharides from algae with potential biomedical applications. Mar Drugs. 2015; 13(5):2967-3028. PMC: 4446615. DOI: 10.3390/md13052967. View

11.

Sousa A, Alves V, Morais S, Delerue-Matos C, Goncalves M . Agar extraction from integrated multitrophic aquacultured Gracilaria vermiculophylla: evaluation of a microwave-assisted process using response surface methodology. Bioresour Technol. 2010; 101(9):3258-67. DOI: 10.1016/j.biortech.2009.12.061. View

12.

Shukla D, Liu J, Blaiklock P, Shworak N, Bai X, Esko J . A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry. Cell. 1999; 99(1):13-22. DOI: 10.1016/s0092-8674(00)80058-6. View

13.

Sun L, Wang L, Li J, Liu H . Characterization and antioxidant activities of degraded polysaccharides from two marine Chrysophyta. Food Chem. 2014; 160:1-7. DOI: 10.1016/j.foodchem.2014.03.067. View

14.

Perez-Recalde M, Matulewicz M, Pujol C, Carlucci M . In vitro and in vivo immunomodulatory activity of sulfated polysaccharides from red seaweed Nemalion helminthoides. Int J Biol Macromol. 2014; 63:38-42. DOI: 10.1016/j.ijbiomac.2013.10.024. View

15.

Kadam S, Tiwari B, ODonnell C . Application of novel extraction technologies for bioactives from marine algae. J Agric Food Chem. 2013; 61(20):4667-75. DOI: 10.1021/jf400819p. View

16.

Wang X, Zhang Z, Yao Z, Zhao M, Qi H . Sulfation, anticoagulant and antioxidant activities of polysaccharide from green algae Enteromorpha linza. Int J Biol Macromol. 2013; 58:225-30. DOI: 10.1016/j.ijbiomac.2013.04.005. View

17.

Anastyuk S, Shevchenko N, Usoltseva Menshova R, Silchenko A, Zadorozhny P, Dmitrenok P . Structural features and anticancer activity in vitro of fucoidan derivatives from brown alga Saccharina cichorioides. Carbohydr Polym. 2016; 157:1503-1510. DOI: 10.1016/j.carbpol.2016.11.031. View

18.

Zayed A, Muffler K, Hahn T, Rupp S, Finkelmeier D, Burger-Kentischer A . Physicochemical and Biological Characterization of Fucoidan from Fucus vesiculosus Purified by Dye Affinity Chromatography. Mar Drugs. 2016; 14(4). PMC: 4849083. DOI: 10.3390/md14040079. View

19.

Kravchenko A, Anastyuk S, Isakov V, Sokolova E, Glazunov V, Yermak I . Structural peculiarities of polysaccharide from sterile form of Far Eastern red alga Ahnfeltiopsis flabelliformis. Carbohydr Polym. 2014; 111:1-9. DOI: 10.1016/j.carbpol.2014.04.022. View

20.

Harazono A, Kobayashi T, Kawasaki N, Itoh S, Tada M, Hashii N . A comparative study of monosaccharide composition analysis as a carbohydrate test for biopharmaceuticals. Biologicals. 2011; 39(3):171-80. DOI: 10.1016/j.biologicals.2011.04.002. View