Migraine Treatment: Current Acute Medications and Their Potential Mechanisms of Action

Overview

Journal Neurotherapeutics

Specialty Neurology

Date 2017 Dec 14

PMID 29235068

Citations 54

Authors

Jonathan Jia Yuan Ong

Milena De Felice

Affiliations

Soon will be listed here.

Abstract

Migraine is a common and disabling primary headache disorder with a significant socioeconomic burden. The management of migraine is multifaceted and is generally dichotomized into acute and preventive strategies, with several treatment modalities. The aims of acute pharmacological treatment are to rapidly restore function with minimal recurrence, with the avoidance of side effects. The choice of pharmacological treatment is individualized, and is based on the consideration of the characteristics of the migraine attack, the patient's concomitant medical problems, and treatment preferences. Notwithstanding, a good understanding of the pharmacodynamic and pharmacokinetic properties of the various drug options is essential to guide therapy. The current approach and concepts relevant to the acute pharmacological treatment of migraine will be explored in this review.

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