The Successful Treatment of a Case of Linear Psoriasis with Ixekizumab

Overview

Journal Case Rep Dermatol Med

Publisher Wiley

Specialty Dermatology

Date 2017 Dec 13

PMID 29230331

Citations 3

Authors

Sara Ghoneim

Alvaro J Ramos-Rodriguez

Fernando Vazquez de Lara

Lauren Bonomo

Affiliations

Soon will be listed here.

Abstract

Linear psoriasis is an unusual clinical variation of psoriasis that manifests segmentally along the lines of Blaschko. A major differential diagnosis is inflammatory linear verrucous epidermal nevus (ILVEN). The treatment of linear psoriasis is often challenging, with inadequate response to biological agents reported in the literature. We report a case of a 25-year-old African-American female who presented with asymptomatic hyperkeratotic papules along the lines of Blaschko and was subsequently diagnosed with linear psoriasis. After failing conventional treatment regimens, the patient received a trial of ixekizumab with complete resolution of cutaneous lesions reported after 4 months and only 8 doses of the anti-IL-17 biologic agent.

Citing Articles

Successful Treatment of Linear Psoriasis With the IL-17a-Antagonist Ixekizumab: A Case Report.

Christov S, Ohm F, Augustin M, Wagner J Psoriasis (Auckl). 2025; 15:23-28.

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Anti-tumor necrosis factor-alpha inhibitor-induced linear psoriasis: A case report.

MacIntyre O, Purdy K SAGE Open Med Case Rep. 2024; 12:2050313X241304954.

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Clinical Characteristics and Therapeutic Aspects of Blaschko Linear Psoriasis.

Chen L, Cheng Y, Peng L, Jia X, Liu G, Shen Z Dermatol Ther (Heidelb). 2024; 14(4):1039-1048.

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Successful Treatment of Inflammatory Linear Verrucous Epidermal Nevus with Concomitant Psoriasis Using Etanercept.

Saifaldeen R, Fatani M, Baltow B, Khan A Case Rep Dermatol. 2018; 10(1):29-34.

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