A Mechanistic Review on Medicinal Plants Used for Diabetes Mellitus in Traditional Persian Medicine

Overview

Journal J Evid Based Complementary Altern Med

Publisher Sage Publications

Specialty Rehabilitation Medicine

Date 2017 Dec 13

PMID 29228789

Citations 20

Authors

Fatemeh Farzaei

Mohammad Reza Morovati

Fatemeh Farjadmand

Mohammad Hosein Farzaei

Affiliations

Soon will be listed here.

Abstract

Diabetes mellitus is the most common endocrine disorder and a major cause of morbidity and mortality. Traditional medicines worldwide suggest a wide range of natural remedies for the prevention and treatment of chronic disorders, including diabetes mellitus. This mechanistic review aims to highlight the significance of medicinal plants traditionally used as dietary supplements in Persian medicine in adjunct with restricted conventional drugs for the prevention and treatment of diabetes mellitus. Mounting evidence suggests that these natural agents perform their protective and therapeutic effect on diabetes mellitus via several cellular mechanisms, including regeneration of pancreatic β cell, limitation of glycogen degradation and gluconeogenesis, anti-inflammatory, immunoregulatory, antiapoptosis, antioxidative stress, as well as modulation of intracellular signaling transduction pathways. In conclusion, traditional medicinal plants used in Persian medicine can be considered as dietary supplements with therapeutic potential for diabetes mellitus and maybe potential sources of new orally active agent(s).

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References

Lee A, Lee Y, Lee S, Yoon J, Kim J, Kang D . Portulaca oleracea Ameliorates Diabetic Vascular Inflammation and Endothelial Dysfunction in db/db Mice. Evid Based Complement Alternat Med. 2012; 2012:741824. PMC: 3303738. DOI: 10.1155/2012/741824. View

Jin H, Cha Y, Baek H, Park T . Neuroprotective effects of Vitis vinifera extract on prediabetic mice induced by a high-fat diet. Korean J Intern Med. 2013; 28(5):579-86. PMC: 3759764. DOI: 10.3904/kjim.2013.28.5.579. View

Gholamhoseinian A, Fallah H, Sharifi far F . Inhibitory effect of methanol extract of Rosa damascena Mill. flowers on alpha-glucosidase activity and postprandial hyperglycemia in normal and diabetic rats. Phytomedicine. 2009; 16(10):935-41. DOI: 10.1016/j.phymed.2009.02.020. View

Ahmed D, Sharma M, Mukerjee A, Ramteke P, Kumar V . Improved glycemic control, pancreas protective and hepatoprotective effect by traditional poly-herbal formulation "Qurs Tabasheer" in streptozotocin induced diabetic rats. BMC Complement Altern Med. 2013; 13:10. PMC: 3564698. DOI: 10.1186/1472-6882-13-10. View

Bahramsoltani R, Farzaei M, Farahani M, Rahimi R . Phytochemical constituents as future antidepressants: a comprehensive review. Rev Neurosci. 2015; 26(6):699-719. DOI: 10.1515/revneuro-2015-0009. View

Thorpe S, Baynes J . Role of the Maillard reaction in diabetes mellitus and diseases of aging. Drugs Aging. 1996; 9(2):69-77. DOI: 10.2165/00002512-199609020-00001. View

Gray A, Flatt P . Insulin-releasing and insulin-like activity of the traditional anti-diabetic plant Coriandrum sativum (coriander). Br J Nutr. 1999; 81(3):203-9. DOI: 10.1017/s0007114599000392. View

Shukla K, Dikshit P, Tyagi M, Shukla R, Gambhir J . Ameliorative effect of Withania coagulans on dyslipidemia and oxidative stress in nicotinamide-streptozotocin induced diabetes mellitus. Food Chem Toxicol. 2012; 50(10):3595-9. DOI: 10.1016/j.fct.2012.07.026. View

Wadood A, Wadood N, Shah S . Effects of Acacia arabica and Caralluma edulis on blood glucose levels of normal and alloxan diabetic rabbits. J Pak Med Assoc. 1989; 39(8):208-12. View

10.

Mathers C, Loncar D . Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med. 2006; 3(11):e442. PMC: 1664601. DOI: 10.1371/journal.pmed.0030442. View

11.

Bagri P, Ali M, Aeri V, Bhowmik M, Sultana S . Antidiabetic effect of Punica granatum flowers: effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes. Food Chem Toxicol. 2008; 47(1):50-4. DOI: 10.1016/j.fct.2008.09.058. View

12.

El-Sayed M . Effects of Portulaca oleracea L. seeds in treatment of type-2 diabetes mellitus patients as adjunctive and alternative therapy. J Ethnopharmacol. 2011; 137(1):643-51. DOI: 10.1016/j.jep.2011.06.020. View

13.

Li Y, Wen S, Kota B, Peng G, Li G, Yamahara J . Punica granatum flower extract, a potent alpha-glucosidase inhibitor, improves postprandial hyperglycemia in Zucker diabetic fatty rats. J Ethnopharmacol. 2005; 99(2):239-44. DOI: 10.1016/j.jep.2005.02.030. View

14.

Sepici-Dincel A, Acikgoz S, Cevik C, Sengelen M, Yesilada E . Effects of in vivo antioxidant enzyme activities of myrtle oil in normoglycaemic and alloxan diabetic rabbits. J Ethnopharmacol. 2006; 110(3):498-503. DOI: 10.1016/j.jep.2006.10.015. View

15.

Pradeepa R, Mohan V . The changing scenario of the diabetes epidemic: implications for India. Indian J Med Res. 2003; 116:121-32. View

16.

Medagama A, Bandara R . The use of complementary and alternative medicines (CAMs) in the treatment of diabetes mellitus: is continued use safe and effective?. Nutr J. 2014; 13:102. PMC: 4210501. DOI: 10.1186/1475-2891-13-102. View

17.

Sen S, Roy M, Chakraborti A . Ameliorative effects of glycyrrhizin on streptozotocin-induced diabetes in rats. J Pharm Pharmacol. 2011; 63(2):287-96. DOI: 10.1111/j.2042-7158.2010.01217.x. View

18.

Pinent M, Blay M, Blade M, Salvado M, Arola L, Ardevol A . Grape seed-derived procyanidins have an antihyperglycemic effect in streptozotocin-induced diabetic rats and insulinomimetic activity in insulin-sensitive cell lines. Endocrinology. 2004; 145(11):4985-90. DOI: 10.1210/en.2004-0764. View

19.

Wild S, Roglic G, Green A, Sicree R, King H . Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004; 27(5):1047-53. DOI: 10.2337/diacare.27.5.1047. View

20.

Rama Rao A, Veeresham C, Asres K . In vitro and in vivo inhibitory activities of four Indian medicinal plant extracts and their major components on rat aldose reductase and generation of advanced glycation endproducts. Phytother Res. 2012; 27(5):753-60. DOI: 10.1002/ptr.4786. View