The Effects of Addition of Coenzyme Q10 to Metformin on Sirolimus-induced Diabetes Mellitus

Overview

Journal Korean J Intern Med

Specialty General Medicine

Date 2017 Dec 13

PMID 29228766

Citations 8

Authors

In O Sun

Long Jin

Jian Jin

Sun Woo Lim

Byung Ha Chung

Chul Woo Yang

Affiliations

Soon will be listed here.

Abstract

Background/aims: This study was performed to determine whether adding coenzyme Q10 (CoQ10) to metformin (MET) has a beneficial effect as a treatment for sirolimus (SRL)-induced diabetes mellitus (DM).

Methods: DM was induced in rats by daily treatment with SRL (0.3 mg/kg, subcutaneous) for 28 days, and animals were treated with CoQ10 (20 mg/kg, oral) and MET (250 mg/kg, oral) alone or in combination for the latter 14 days of SRL treatment. The effects of CoQ10 and MET on SRL-induced DM were assessed with the intraperitoneal glucose tolerance test (IPGTT) and by determining plasma insulin concentration and the homeostatic model assessment of insulin resistance (HOMA-R) index. We also evaluated the effect of CoQ10 on pancreatic islet size, apoptosis, oxidative stress, and mitochondria morphology.

Results: IPGTT revealed overt DM in SRL-treated rats. The addition of CoQ10 to MET further improved hyperglycemia, decreased HOMA-R index, and increased plasma insulin concentration compared with the SRL group than MET alone therapy. While SRL treatment induced smaller islets with decreased insulin staining intensity, the combination of CoQ10 and MET significantly improved insulin staining intensity, which was accompanied by a reduction in oxidative stress and apoptosis. In addition, co-treatment of CoQ10 and MET significantly increased the levels of antiperoxidative enzymes in the pancreas islet cells compared with MET. At the subcellular level, addition of CoQ10 to MET improved the average mitochondrial area and insulin granule number.

Conclusion: Addition of CoQ10 to MET has a beneficial effect on SRL-induced DM compared to MET alone.

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The therapeutic efficacy of water-soluble coenzyme Q10 in an experimental model of tacrolimus-induced diabetes mellitus.

Quan Y, Luo K, Cui S, Lim S, Shin Y, Ko E Korean J Intern Med. 2020; 35(6):1443-1456.

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