Bone Marrow Stem Cells-derived Extracellular Matrix is a Promising Material

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Dec 13

PMID 29228693

Citations 3

Authors

Xiaoyan Wang

Guanghua Chen

Chao Huang

Hualei Tu

Jilong Zou

Jinglong Yan

Affiliations

Soon will be listed here.

Abstract

The extracellular matrix(ECM), which is primarily composed of collagens and proteoglycans, plays a key role in cell proliferation, differentiation, and migration and interactions between cells. In this study, we produced chitosan/gelatin/bone marrow stem cells-derived extracellular matrix(C/G/BMSCs-dECM) scaffolds via lyophilization and cross-linking, and chitosan/gelatin(C/G) scaffolds were used as controls. For the C/G/BMSCs-dECM scaffolds, the average pore size was 289.17 ± 80.28 μm; the average porosity was 89.25 ± 3.75%; the average compressive modulus was 0.82 ± 0.07 MPa; and the average water uptake ratio was 13.81 ± 1.00. , the C/G/BMSCs-dECM scaffolds promoted bone marrow stem cells(BMSCs) attachment and proliferation. Moreover, improved osteogenic differentiation was observed for these scaffolds. Thus, C/G/BMSCs-dECM is a promising material for bone tissue engineering.

Citing Articles

Development of a Biomimetic Hydrogel Based on Predifferentiated Mesenchymal Stem-Cell-Derived ECM for Cartilage Tissue Engineering.

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PMID: 33646595 PMC: 11468687. DOI: 10.1002/adhm.202001847.

3D-HA Scaffold Functionalized by Extracellular Matrix of Stem Cells Promotes Bone Repair.

Chi H, Chen G, He Y, Chen G, Tu H, Liu X Int J Nanomedicine. 2020; 15:5825-5838.

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Activated Mesenchymal Stem Cells Induce Recovery Following Stroke Via Regulation of Inflammation and Oligodendrogenesis.

Tobin M, Stephen T, Lopez K, Pergande M, Bartholomew A, Cologna S J Am Heart Assoc. 2020; 9(7):e013583.

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