Phenotypic Plasticity in the Pancreas: New Triggers, New Players

Overview

Journal Curr Opin Cell Biol

Publisher Elsevier

Specialty Cell Biology

Date 2017 Dec 12

PMID 29227863

Citations 7

Authors

Theoni Ingrid Demcollari

Ana-Maria Cujba

Rocio Sancho

Affiliations

Soon will be listed here.

Abstract

The pancreas has a very limited regenerative potential during homeostasis. Despite its quiescent nature, recent in vivo models suggest a certain degree of regeneration and cellular interconversion is possible within the adult pancreas. It has now become evident that cellular plasticity can be observed in essentially all cell types within the pancreas when provided with the right stress stimuli. In this review, we will focus on the latest findings uncovering phenotypic plasticity of different cell types in the pancreas, the molecular mechanisms behind such plasticity and how plasticity associated with pancreatic or non-pancreatic cells could be harnessed in the generation of new insulin-producing beta cells.

Citing Articles

β-Cell Regeneration Is Driven by Pancreatic Plasticity.

Holguin-Horcajo A, Sancho R, Rovira M Adv Anat Embryol Cell Biol. 2024; 239:91-115.

PMID: 39283483 DOI: 10.1007/978-3-031-62232-8_4.

EpiCRISPR targeted methylation of Arx gene initiates transient switch of mouse pancreatic alpha to insulin-producing cells.

dordevic M, Stepper P, Feuerstein-Akgoz C, Gerhauser C, Paunovic V, Tolic A Front Endocrinol (Lausanne). 2023; 14:1134478.

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Stem/progenitor cells in normal physiology and disease of the pancreas.

Alvarez Fallas M, Pedraza-Arevalo S, Cujba A, Manea T, Lambert C, Morrugares R Mol Cell Endocrinol. 2021; 538:111459.

PMID: 34543699 PMC: 8573583. DOI: 10.1016/j.mce.2021.111459.

Exocrine pancreas proteases regulate β-cell proliferation in zebrafish ciliopathy models and in murine systems.

Hostelley T, Nesmith J, Larkin E, Jones A, Boyes D, Leitch C Biol Open. 2021; 10(6).

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Protease-activated receptor 1 drives and maintains ductal cell fates in the premalignant pancreas and ductal adenocarcinoma.

Tekin C, Scicluna B, Lodestijn S, Shi K, Bijlsma M, Spek C Mol Oncol. 2021; 15(11):3091-3108.

PMID: 33932087 PMC: 8564660. DOI: 10.1002/1878-0261.12971.

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