Potential Diagnostic Markers of Olanzapine Efficiency for Acute Psychosis: a Focus on Peripheral Biogenic Amines

Overview

Journal BMC Psychiatry

Publisher Biomed Central

Specialty Psychiatry

Date 2017 Dec 10

PMID 29221470

Citations 6

Authors

A E Taraskina

R F Nasyrova

A M Zabotina

D N Sosin

K A Sosina

E E Ershov

M N Grunina

E M Krupitsky

Affiliations

Soon will be listed here.

Abstract

Background: Biomarkers are now widely used in many fields of medicine, and the identification of biomarkers that predict antipsychotic efficacy and adverse reactions is a growing area of psychiatric research. Monoamine molecules of the peripheral bloodstream are possible prospective biomarkers based on a growing body of evidence indicating that they may reflect specific changes in neurotransmitters in the brain. The aim of this study was to detect peripheral biogenic amine indicators of patients with acute psychosis and to test the correlations between the biological measures studied and the psychopathological status of the patients.

Methods: This research included 60 patients with acute psychosis treated with olanzapine (n = 30) or haloperidol (n = 30). Here, we measured biogenic amine indicators, including mRNA levels of dopamine receptor D4 (DRD4) and the serotonin 2A receptor (5HTR2A), in peripheral blood mononuclear cells (PBMCs) using quantitative real-time polymerase chain reaction and serum dopamine concentrations by enzyme linked immunosorbent assay (ELISA). Psychopathological status was evaluated using psychometric scales. The assessments were conducted prior to and after 14 and 28 days of treatment.

Results: The administration of haloperidol, but not olanzapine, up-regulated 5HTR2A mRNA in a linear manner, albeit without statistical significance (p = 0.052). Both drugs had non-significant effects on DRD4 mRNA levels. Nevertheless, a positive correlation was found between DRD4 and 5HTR2A mRNA levels over a longitudinal trajectory, suggesting co-expression of the two genes. A significant positive correlation was observed between 5HTR2A mRNA levels and total Positive and Negative Syndrome Scale (PANSS) scores in both groups of patients before treatment. A significant correlation between baseline 5HTR2A mRNA levels and PANSS scores on days 14 and 28 of treatment remained for patients treated with olanzapine only. Moreover, a significant positive correlation was observed between blood serum dopamine levels and scores on extrapyramidal symptom scales in the olanzapine group.

Conclusions: The DRD4 and 5HTR2A genes are co-expressed in PBMCs during antipsychotic administration. Despite a correlation between the studied biogenic amine indicators and the psychopathological status of patients, reliable biomarkers of treatment response could not be determined.

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References

Kwak Y, Koo M, Choi C, Sunwoo I . Change of dopamine receptor mRNA expression in lymphocyte of schizophrenic patients. BMC Med Genet. 2001; 2:3. PMC: 29096. DOI: 10.1186/1471-2350-2-3. View

Buttarelli F, Fanciulli A, Pellicano C, Pontieri F . The dopaminergic system in peripheral blood lymphocytes: from physiology to pharmacology and potential applications to neuropsychiatric disorders. Curr Neuropharmacol. 2011; 9(2):278-88. PMC: 3131719. DOI: 10.2174/157015911795596612. View

DSouza U, Russ C, Tahir E, Mill J, McGuffin P, Asherson P . Functional effects of a tandem duplication polymorphism in the 5'flanking region of the DRD4 gene. Biol Psychiatry. 2004; 56(9):691-7. DOI: 10.1016/j.biopsych.2004.08.008. View

Zhan L, Kerr J, Lafuente M, MacLean A, Chibalina M, Liu B . Altered expression and coregulation of dopamine signalling genes in schizophrenia and bipolar disorder. Neuropathol Appl Neurobiol. 2010; 37(2):206-19. DOI: 10.1111/j.1365-2990.2010.01128.x. View

Thibaut F . Acute treatment of schizophrenia: introduction to the Word Federation of Societies of Biological Psychiatry guidelines. Psychiatr Danub. 2014; 26(1):2-11. View

Carlsson A . A paradigm shift in brain research. Science. 2001; 294(5544):1021-4. DOI: 10.1126/science.1066969. View

Grunder G, Heinze M, Cordes J, Muhlbauer B, Juckel G, Schulz C . Effects of first-generation antipsychotics versus second-generation antipsychotics on quality of life in schizophrenia: a double-blind, randomised study. Lancet Psychiatry. 2016; 3(8):717-729. DOI: 10.1016/S2215-0366(16)00085-7. View

Lai C, Scarr E, Udawela M, Everall I, Chen W, Dean B . Biomarkers in schizophrenia: A focus on blood based diagnostics and theranostics. World J Psychiatry. 2016; 6(1):102-17. PMC: 4804259. DOI: 10.5498/wjp.v6.i1.102. View

Boneberg E, von Seydlitz E, Propster K, Watzl H, Rockstroh B, Illges H . D3 dopamine receptor mRNA is elevated in T cells of schizophrenic patients whereas D4 dopamine receptor mRNA is reduced in CD4+ -T cells. J Neuroimmunol. 2005; 173(1-2):180-7. DOI: 10.1016/j.jneuroim.2005.11.018. View

10.

Liu M, Luo J . Relationship between peripheral blood dopamine level and internet addiction disorder in adolescents: a pilot study. Int J Clin Exp Med. 2015; 8(6):9943-8. PMC: 4538113. View

11.

Rollins B, Martin M, Morgan L, Vawter M . Analysis of whole genome biomarker expression in blood and brain. Am J Med Genet B Neuropsychiatr Genet. 2010; 153B(4):919-36. PMC: 3098564. DOI: 10.1002/ajmg.b.31062. View

12.

Smith R, Papp A, Webb A, Ruble C, Munsie L, Nisenbaum L . Multiple regulatory variants modulate expression of 5-hydroxytryptamine 2A receptors in human cortex. Biol Psychiatry. 2012; 73(6):546-54. PMC: 3582836. DOI: 10.1016/j.biopsych.2012.09.028. View

13.

Cui Y, Prabhu V, Nguyen T, Yadav B, Chung Y . The mRNA Expression Status of Dopamine Receptor D2, Dopamine Receptor D3 and DARPP-32 in T Lymphocytes of Patients with Early Psychosis. Int J Mol Sci. 2015; 16(11):26677-86. PMC: 4661842. DOI: 10.3390/ijms161125983. View

14.

Matthysse S . Antipsychotic drug actions: a clue to the neuropathology of schizophrenia?. Fed Proc. 1973; 32(2):200-5. View

15.

Mostafavi Abdolmaleky H, Faraone S, Glatt S, Tsuang M . Meta-analysis of association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia. Schizophr Res. 2004; 67(1):53-62. DOI: 10.1016/s0920-9964(03)00183-x. View

16.

Goff D, Romero K, Paul J, Perez-Rodriguez M, Crandall D, Potkin S . Biomarkers for drug development in early psychosis: Current issues and promising directions. Eur Neuropsychopharmacol. 2016; 26(6):923-37. DOI: 10.1016/j.euroneuro.2016.01.009. View

17.

Crossley N, Constante M, McGuire P, Power P . Efficacy of atypical v. typical antipsychotics in the treatment of early psychosis: meta-analysis. Br J Psychiatry. 2010; 196(6):434-9. PMC: 2878818. DOI: 10.1192/bjp.bp.109.066217. View

18.

Bergquist J, Tarkowski A, Ekman R, Ewing A . Discovery of endogenous catecholamines in lymphocytes and evidence for catecholamine regulation of lymphocyte function via an autocrine loop. Proc Natl Acad Sci U S A. 1994; 91(26):12912-6. PMC: 45550. DOI: 10.1073/pnas.91.26.12912. View

19.

Apiquian R, Fresan A, de la Fuente-Sandoval C, Ulloa R, Nicolini H . Survey on schizophrenia treatment in Mexico: perception and antipsychotic prescription patterns. BMC Psychiatry. 2004; 4:12. PMC: 416660. DOI: 10.1186/1471-244X-4-12. View

20.

Moussouttas M, Mearns E, Walters A, Decaro M . Plasma Catecholamine Profile of Subarachnoid Hemorrhage Patients with Neurogenic Cardiomyopathy. Cerebrovasc Dis Extra. 2015; 5(2):57-67. PMC: 4478315. DOI: 10.1159/000431155. View