Cognitive Impairment in Spinocerebellar Ataxia Type 10

Overview

Journal Dement Neuropsychol

Date 2017 Dec 8

PMID 29213474

Citations 4

Authors

Adriana Moro

Helio Afonso Ghizoni Teive

Affiliations

Soon will be listed here.

Abstract

Background: Cognitive and psychiatric dysfunction has been described in several neurodegenerative diseases but has not been systematically evaluated in spinocerebellar ataxia type 10 (SCA10).

Objective: The aim of the present study was to investigate the core cognitive features in a large cohort of Brazilian patients with SCA10, comparing the results against a healthy control group.

Methods: Twenty-eight SCA10 and 28 healthy subjects were prospectively assessed regarding cognitive function and psychiatric disorders at the Movement Disorders Unit of the Federal University of Paraná between February 2012 and October 2014.

Results: The SCA10 group had worse depression scores, as well as cognitive performance, when compared to healthy individuals.

Conclusion: Our study showed mild cognitive and mood dysfunctions in patients with SCA10, consistent with the symptoms reported in the Cerebellar Cognitive Affective Syndrome described by Schmahmann JD in 1998. The description of these findings is an important clinical phenomenon that may guide physicians in specific disease management and improve quality of life of these patients.

Citing Articles

Cognition in cerebellar disorders: What's in the profile? A systematic review and meta-analysis.

Reumers S, Bongaerts F, de Leeuw F, van de Warrenburg B, Schutter D, Kessels R J Neurol. 2025; 272(3):250.

PMID: 40047904 PMC: 11885410. DOI: 10.1007/s00415-025-12967-8.

Cerebellar cognitive affective syndrome in patients with spinocerebellar ataxia type 10.

Romero-Molina A, Ramirez-Garcia G, Chirino-Perez A, Padron-Rivera G, Hernandez-Castillo C, Garcia-Gomar M PLoS One. 2025; 20(3):e0319505.

PMID: 40029932 PMC: 11875346. DOI: 10.1371/journal.pone.0319505.

Non-motor symptoms in patients with Spinocerebellar ataxia type 12.

Basu P, Choudhury S, Mondal S, Siddique U, Rahman S, Ganguly J Front Neurol. 2024; 15:1464149.

PMID: 39469072 PMC: 11513432. DOI: 10.3389/fneur.2024.1464149.

Cognitive Dysfunction in Repeat Expansion Diseases: A Review.

Zhang S, Shen L, Jiao B Front Aging Neurosci. 2022; 14:841711.

PMID: 35478698 PMC: 9036481. DOI: 10.3389/fnagi.2022.841711.

The Relationships Between Ataxia and Cognition in Spinocerebellar Ataxia Type 2.

Gigante A, Lelli G, Romano R, Pellicciari R, Di Candia A, Mancino P Cerebellum. 2019; 19(1):40-47.

PMID: 31637587 DOI: 10.1007/s12311-019-01079-5.

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