Low Levels of Sex Hormone-Binding Globulin Constitute an Independent Risk Factor for Arterial Stiffness in Korean Women

Overview

Journal Int J Endocrinol

Publisher Wiley

Specialty Endocrinology

Date 2017 Dec 8

PMID 29213285

Citations 2

Authors

Kunhee Han

Hyejin Chun

Moon-Jong Kim

Doo-Yeoun Cho

Soo-Hyun Lee

Bo Youn Won

Kwang-Min Kim

Nam-Seok Joo

Young-Sang Kim

Affiliations

Soon will be listed here.

Abstract

The association between sex hormone-binding globulin (SHBG) and arterial stiffness in women is not conclusive. In addition, obesity might also be involved in the relationship between SHBG and atherosclerosis. The aim of this study was to determine the relationship between SHBG and arterial stiffness in association with central obesity in women. This cross-sectional study included 381 women who participated in the health checkup programs in one hospital. The brachial-ankle pulse wave velocity (baPWV) was measured as a marker for arterial stiffness. A negative correlation was observed between SHBG levels and baPWV (rho = -0.281). The relationship was significant even after adjusting for potential confounders (beta = -0.087 in fully adjusted model). After considering the interaction between central obesity and SHBG levels, the significant association was evident only in obese women ( for interaction = 0.025). Adjustment for a 10-year atherosclerotic cardiovascular disease (ASCVD) risk scores, instead of each cardiovascular risk factor individually, did not affect the significance of the relationship between SHBG levels and baPWV. Serum levels of SHBG were negatively associated with arterial stiffness independent of cardiovascular risk factors or 10-year ASCVD risk scores in Korean women. The relationship may be potentiated by central obesity.

Citing Articles

Relationship of Noninvasive Assessment of Arterial Stiffness with 10-Year Atherosclerotic Cardiovascular Disease (ASCVD) Risk in a General Middle-Age and Elderly Population.

Wang H, Wu X, Gu Y, Zhou J, Wu J Int J Gen Med. 2021; 14:6379-6387.

PMID: 34934340 PMC: 8678628. DOI: 10.2147/IJGM.S330142.

Definition, Prevalence, and Risk Factors of Low Sex Hormone-Binding Globulin in US Adults.

Wang Y J Clin Endocrinol Metab. 2021; 106(10):e3946-e3956.

PMID: 34125885 PMC: 8571812. DOI: 10.1210/clinem/dgab416.

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