Evaluating Antidisease Immunity to Malaria and Implications for Vaccine Design

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 2017 Dec 7

PMID 29211303

Citations 18

Authors

Temitope W Ademolue

Gordon A Awandare

Affiliations

Soon will be listed here.

Abstract

Immunity to malaria could be categorized broadly as antiparasite or antidisease immunity. While most vaccine research efforts have focused on antiparasite immunity, the evidence from endemic populations suggest that antidisease immunity is an important component of natural immunity to malaria. The processes that mediate antidisease immunity have, however, attracted little to no attention, and most interests have been directed towards the antibody responses. This review evaluates the evidence for antidisease immunity in endemic areas and discusses the possible mechanisms responsible for it. Given the key role that inflammation plays in the pathogenesis of malaria, regulation of the inflammatory response appears to be a major mechanism for antidisease immunity in naturally exposed individuals.

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