Expression of Folate-sensitive Fragile Sites in Lymphocyte Chromosomes

Overview

Journal Hum Genet

Specialty Genetics

Date 1989 Feb 1

PMID 2921033

Citations 3

Authors

C Fuster

R Miro

C Templado

L Barrios

J Egozcue

Affiliations

Soon will be listed here.

Abstract

The expression of folate-sensitive fragile sites (FS) was analyzed using MTX as a fragility inducer in seven normal subjects [four unrelated persons and three members of one family (father, mother, and son)]; a woman heterozygous for fra Xq27.3 with a 47,XXX karyotype; and her son, affected by the fra-X syndrome. The mean expression of chromosome lesions (CL) other than Xq27.3 was 70.1% (686CL in 978 metaphases), and the coincidence between CL and FS was 68.9%. We propose six new c-fra sites: bands 4q33 and 11q22 because they were found in two members of the same family; band 13q32 because it had a frequency of expression of 3% of metaphases; and bands 3p13, 8q21, and Xq21 because they were observed in four of the nine individuals studied.

Citing Articles

Telomere association of chromosomes induced by aphidicolin in a normal individual.

Fuster C, Miro R, Barrios L, Egozcue J Hum Genet. 1990; 84(5):424-6.

PMID: 2108923 DOI: 10.1007/BF00195813.

Cytogenetic studies in motile sperm from normal men.

Benet J, Genesca A, Navarro J, Egozcue J, Templado C Hum Genet. 1992; 89(2):176-80.

PMID: 1587528 DOI: 10.1007/BF00217119.

Increased expression of 5q31 fragile site in a Bloom syndrome family.

Fundia A, Gorla N, Bonduel M, Azpilicueta O, Lejarraga H, Muriel F Hum Genet. 1992; 89(5):569-72.

PMID: 1386058 DOI: 10.1007/BF00219187.

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