Trial Watch: DNA-based Vaccines for Oncological Indications

Overview

Journal Oncoimmunology

Specialty Allergy & Immunology

Date 2017 Dec 7

PMID 29209575

Citations 19

Authors

Stefano Pierini

Renzo Perales-Linares

Mireia Uribe-Herranz

Jonathan G Pol

Laurence Zitvogel

Guido Kroemer

Andrea Facciabene

Lorenzo Galluzzi

Affiliations

Soon will be listed here.

Abstract

DNA-based vaccination is a promising approach to cancer immunotherapy. DNA-based vaccines specific for tumor-associated antigens (TAAs) are indeed relatively simple to produce, cost-efficient and well tolerated. However, the clinical efficacy of DNA-based vaccines for cancer therapy is considerably limited by central and peripheral tolerance. During the past decade, considerable efforts have been devoted to the development and characterization of novel DNA-based vaccines that would circumvent this obstacle. In this setting, particular attention has been dedicated to the route of administration, expression of modified TAAs, co-expression of immunostimulatory molecules, and co-delivery of immune checkpoint blockers. Here, we review preclinical and clinical progress on DNA-based vaccines for cancer therapy.

Citing Articles

CEA vaccines.

Bhagat A, Lyerly H, Morse M, Hartman Z Hum Vaccin Immunother. 2023; 19(3):2291857.

PMID: 38087989 PMC: 10732609. DOI: 10.1080/21645515.2023.2291857.

Vaccines in Breast Cancer: Challenges and Breakthroughs.

Fatima G, Fatma H, Saraf S Diagnostics (Basel). 2023; 13(13).

PMID: 37443570 PMC: 10340541. DOI: 10.3390/diagnostics13132175.

Preclinical study of a DNA vaccine targeting SARS-CoV-2.

Hayashi H, Sun J, Yanagida Y, Otera T, Kubota-Koketsu R, Shioda T Curr Res Transl Med. 2022; 70(4):103348.

PMID: 35489099 PMC: 9020527. DOI: 10.1016/j.retram.2022.103348.

Vaccines as Priming Tools for T Cell Therapy for Epithelial Cancers.

Kandalaft L, Harari A Cancers (Basel). 2021; 13(22).

PMID: 34830973 PMC: 8616276. DOI: 10.3390/cancers13225819.

Middle East respiratory syndrome coronavirus vaccine based on a propagation-defective RNA replicon elicited sterilizing immunity in mice.

Gutierrez-Alvarez J, Honrubia J, Sanz-Bravo A, Gonzalez-Miranda E, Fernandez-Delgado R, Rejas M Proc Natl Acad Sci U S A. 2021; 118(43).

PMID: 34686605 PMC: 8639359. DOI: 10.1073/pnas.2111075118.

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