Regulation of Pheromone Biosynthesis in Moths

Female moths release sex pheromones for attracting males from a distance. Most moths are nocturnal so there is a periodicity to the release of sex pheromone. The temporal release of sex pheromone in most moths is regulated by calling behavior and by the biosynthesis of sex pheromone. In most moths, biosynthesis occurs in the pheromone gland and is controlled by the neuropeptide PBAN (pheromone biosynthesis activating neuropeptide). PBAN is produced in the subesophageal ganglion and released into circulation where it travels to the pheromone gland to activate pheromone biosynthesis. The G-protein coupled receptor that binds PBAN has been identified as well as aspects of signal transduction to activate the biosynthetic pathway. This review will highlight recent advances in the study of regulation of pheromone biosynthesis in moths.