Around and Beyond 53BP1 Nuclear Bodies

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2017 Dec 6

PMID 29206178

Citations 18

Authors

Anne Fernandez-Vidal

Julien Vignard

Gladys Mirey

Affiliations

Soon will be listed here.

Abstract

Within the nucleus, sub-nuclear domains define territories where specific functions occur. Nuclear bodies (NBs) are dynamic structures that concentrate nuclear factors and that can be observed microscopically. Recently, NBs containing the p53 binding protein 1 (53BP1), a key component of the DNA damage response, were defined. Interestingly, 53BP1 NBs are visualized during G1 phase, in daughter cells, while DNA damage was generated in mother cells and not properly processed. Unlike most NBs involved in transcriptional processes, replication has proven to be key for 53BP1 NBs, with replication stress leading to the formation of these large chromatin domains in daughter cells. In this review, we expose the composition and organization of 53BP1 NBs and focus on recent findings regarding their regulation and dynamics. We then concentrate on the importance of the replication stress, examine the relation of 53BP1 NBs with DNA damage and discuss their dysfunction.

Citing Articles

Control of cell proliferation by memories of mitosis.

Meitinger F, Belal H, Davis R, Martinez M, Shiau A, Oegema K Science. 2024; 383(6690):1441-1448.

PMID: 38547292 PMC: 11621110. DOI: 10.1126/science.add9528.

Validating Enteroid-Derived Monolayers from Murine Gut Organoids for Toxicological Testing of Inorganic Particles: Proof-of-Concept with Food-Grade Titanium Dioxide.

Malaise Y, Casale E, Pettes-Duler A, Cartier C, Gaultier E, Martins Breyner N Int J Mol Sci. 2024; 25(5).

PMID: 38473881 PMC: 10932210. DOI: 10.3390/ijms25052635.

A New Indicator to Differentiate Thyroid Follicular Inclusions in Cervical Lymph Nodes from Patients with Thyroid Cancer.

Otsubo C, Mussazhanova Z, Kurohama H, Shalgimbayeva G, Ueki N, Matsuoka Y Int J Mol Sci. 2023; 24(1).

PMID: 36613940 PMC: 9820803. DOI: 10.3390/ijms24010490.

Short-Term and Long-Term Carcinogenic Effects of Food Contaminants (4-Hydroxynonenal and Pesticides) on Colorectal Human Cells: Involvement of Genotoxic and Non-Genomic Mechanisms.

Arnaud L, Gauthier T, Le Naour A, Hashim S, Naud N, Shay J Cancers (Basel). 2021; 13(17).

PMID: 34503147 PMC: 8431687. DOI: 10.3390/cancers13174337.

Structural Chromosome Instability: Types, Origins, Consequences, and Therapeutic Opportunities.

Siri S, Martino J, Gottifredi V Cancers (Basel). 2021; 13(12).

PMID: 34205328 PMC: 8234978. DOI: 10.3390/cancers13123056.

References

Kantidze O, Razin S . 5-hydroxymethylcytosine in DNA repair: A new player or a red herring?. Cell Cycle. 2017; 16(16):1499-1501. PMC: 5584847. DOI: 10.1080/15384101.2017.1346761. View

Despras E, Sittewelle M, Pouvelle C, Delrieu N, Cordonnier A, Kannouche P . Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA. Nat Commun. 2016; 7:13326. PMC: 5097173. DOI: 10.1038/ncomms13326. View

Li L, Germain D, Poon H, Hildebrandt M, Monckton E, McDonald D . DEAD Box 1 Facilitates Removal of RNA and Homologous Recombination at DNA Double-Strand Breaks. Mol Cell Biol. 2016; 36(22):2794-2810. PMC: 5086521. DOI: 10.1128/MCB.00415-16. View

Durkin S, Glover T . Chromosome fragile sites. Annu Rev Genet. 2007; 41:169-92. DOI: 10.1146/annurev.genet.41.042007.165900. View

Giunta S, Belotserkovskaya R, Jackson S . DNA damage signaling in response to double-strand breaks during mitosis. J Cell Biol. 2010; 190(2):197-207. PMC: 2930281. DOI: 10.1083/jcb.200911156. View

Stucki M, Clapperton J, Mohammad D, Yaffe M, Smerdon S, Jackson S . MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell. 2005; 123(7):1213-26. DOI: 10.1016/j.cell.2005.09.038. View

Wardlaw C, Carr A, Oliver A . TopBP1: A BRCT-scaffold protein functioning in multiple cellular pathways. DNA Repair (Amst). 2014; 22:165-74. DOI: 10.1016/j.dnarep.2014.06.004. View

Moreno A, Carrington J, Albergante L, Al Mamun M, Haagensen E, Komseli E . Unreplicated DNA remaining from unperturbed S phases passes through mitosis for resolution in daughter cells. Proc Natl Acad Sci U S A. 2016; 113(39):E5757-64. PMC: 5047195. DOI: 10.1073/pnas.1603252113. View

Pombo A, Cuello P, Schul W, Yoon J, Roeder R, Cook P . Regional and temporal specialization in the nucleus: a transcriptionally-active nuclear domain rich in PTF, Oct1 and PIKA antigens associates with specific chromosomes early in the cell cycle. EMBO J. 1998; 17(6):1768-78. PMC: 1170524. DOI: 10.1093/emboj/17.6.1768. View

10.

Matsuda K, Miura S, Kurashige T, Suzuki K, Kondo H, Ihara M . Significance of p53-binding protein 1 nuclear foci in uterine cervical lesions: endogenous DNA double strand breaks and genomic instability during carcinogenesis. Histopathology. 2011; 59(3):441-51. PMC: 3229684. DOI: 10.1111/j.1365-2559.2011.03963.x. View

11.

Muller S, Matunis M, Dejean A . Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus. EMBO J. 1998; 17(1):61-70. PMC: 1170358. DOI: 10.1093/emboj/17.1.61. View

12.

Luebben S, Kawabata T, Johnson C, OSullivan M, Shima N . A concomitant loss of dormant origins and FANCC exacerbates genome instability by impairing DNA replication fork progression. Nucleic Acids Res. 2014; 42(9):5605-15. PMC: 4027174. DOI: 10.1093/nar/gku170. View

13.

Zeman M, Cimprich K . Causes and consequences of replication stress. Nat Cell Biol. 2013; 16(1):2-9. PMC: 4354890. DOI: 10.1038/ncb2897. View

14.

Fradet-Turcotte A, Canny M, Escribano-Diaz C, Orthwein A, Leung C, Huang H . 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark. Nature. 2013; 499(7456):50-4. PMC: 3955401. DOI: 10.1038/nature12318. View

15.

Overton K, Spencer S, Noderer W, Meyer T, Wang C . Basal p21 controls population heterogeneity in cycling and quiescent cell cycle states. Proc Natl Acad Sci U S A. 2014; 111(41):E4386-93. PMC: 4205626. DOI: 10.1073/pnas.1409797111. View

16.

Spencer S, Cappell S, Tsai F, Overton K, Wang C, Meyer T . The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit. Cell. 2013; 155(2):369-83. PMC: 4001917. DOI: 10.1016/j.cell.2013.08.062. View

17.

Thorslund T, Ripplinger A, Hoffmann S, Wild T, Uckelmann M, Villumsen B . Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage. Nature. 2015; 527(7578):389-93. DOI: 10.1038/nature15401. View

18.

Shibata A . Regulation of repair pathway choice at two-ended DNA double-strand breaks. Mutat Res. 2017; 803-805:51-55. DOI: 10.1016/j.mrfmmm.2017.07.011. View

19.

Szostecki C, Guldner H, Will H . Autoantibodies against "nuclear dots" in primary biliary cirrhosis. Semin Liver Dis. 1997; 17(1):71-8. DOI: 10.1055/s-2007-1007184. View

20.

Stanek D, Fox A . Nuclear bodies: news insights into structure and function. Curr Opin Cell Biol. 2017; 46:94-101. DOI: 10.1016/j.ceb.2017.05.001. View