Circulating MicroRNA Signature of Steroid-induced Osteonecrosis of the Femoral Head

Overview

Journal Cell Prolif

Date 2017 Dec 6

PMID 29205600

Citations 22

Authors

Zheng Li

Chao Jiang

Xingye Li

William K K Wu

Xi Chen

Shibai Zhu

Chanhua Ye

Matthew T V Chan

Wenwei Qian

Affiliations

Soon will be listed here.

Abstract

Objectives: Steroid-induced osteonecrosis of the femoral head (ONFH) is a common orthopaedic disease of which early detection remains clinically challenging. Accumulating evidences indicated that circulating microRNAs (miRNAs) plays vital roles in the development of several bone diseases. However, the association between circulating miRNAs and steroid-induced ONFH remains elusive.

Materials And Methods: miRNA microarray was performed to identify the differentially abundant miRNAs in the serums of systemic lupus erythematosus (SLE) patients with steroid-induced ONFH as compared with SLE control and healthy control group. We predicted the potential functions of these differentially abundant miRNAs using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses and reconstructed the regulatory networks of miRNA-mRNA interactions.

Results: Our data indicated that there were 11 differentially abundant miRNAs (2 upregulated and 9 downregulated) between SLE-ONFH group and healthy control group and 42 differentially abundant miRNAs (14 upregulated and 28 downregulated) between SLE-ONFH group and SLE control group. We also predicted the potential functions of these differentially abundant miRNAs using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses and reconstructed the regulatory networks of miRNA-mRNA interactions.

Conclusions: These findings corroborated the idea that circulating miRNAs play significant roles in the development of ONFH and may serve as diagnostic markers and therapeutic targets.

Citing Articles

Investigating the Differential Circulating microRNA Expression in Adolescent Females with Severe Idiopathic Scoliosis: A Proof-of-Concept Observational Clinical Study.

Raimondi L, De Luca A, Gallo A, Perna F, Cuscino N, Cordaro A Int J Mol Sci. 2024; 25(1).

PMID: 38203740 PMC: 10779108. DOI: 10.3390/ijms25010570.

FAR591 promotes the pathogenesis and progression of SONFH by regulating Fos expression to mediate the apoptosis of bone microvascular endothelial cells.

Zhang F, Wei L, Wang L, Wang T, Xie Z, Luo H Bone Res. 2023; 11(1):27.

PMID: 37217464 PMC: 10203311. DOI: 10.1038/s41413-023-00259-8.

Lnc Tmem235 promotes repair of early steroid-induced osteonecrosis of the femoral head by inhibiting hypoxia-induced apoptosis of BMSCs.

Zhang F, Peng W, Wang T, Zhang J, Dong W, Wang C Exp Mol Med. 2022; 54(11):1991-2006.

PMID: 36380019 PMC: 9723185. DOI: 10.1038/s12276-022-00875-0.

Downregulation of miR-30b-5p Facilitates Chondrocyte Hypertrophy and Apoptosis via Targeting Runx2 in Steroid-Induced Osteonecrosis of the Femoral Head.

Lin L, Yu Y, Liu K, Jiang Y, Zhou Z Int J Mol Sci. 2022; 23(19).

PMID: 36232582 PMC: 9570061. DOI: 10.3390/ijms231911275.

Circ_0058792 regulates osteogenic differentiation through miR-181a-5p/Smad7 axis in steroid-induced osteonecrosis of the femoral head.

Han N, Qian F, Niu X, Chen G Bioengineered. 2022; 13(5):12807-12822.

PMID: 35611880 PMC: 9276051. DOI: 10.1080/21655979.2022.2074617.

References

He P, Zhang Z, Huang G, Wang H, Xu D, Liao W . miR-141 modulates osteoblastic cell proliferation by regulating the target gene of lncRNA H19 and lncRNA H19-derived miR-675. Am J Transl Res. 2016; 8(4):1780-8. PMC: 4859907. View

Wang B, Yu P, Li T, Bian Y, Weng X . MicroRNA expression in bone marrow mesenchymal stem cells from mice with steroid-induced osteonecrosis of the femoral head. Mol Med Rep. 2015; 12(5):7447-54. DOI: 10.3892/mmr.2015.4386. View

Hao C, Yang S, Xu W, Shen J, Ye S, Liu X . MiR-708 promotes steroid-induced osteonecrosis of femoral head, suppresses osteogenic differentiation by targeting SMAD3. Sci Rep. 2016; 6:22599. PMC: 4773864. DOI: 10.1038/srep22599. View

Li Z, Yu X, Shen J, Wu W, Chan M . MicroRNA expression and its clinical implications in Ewing's sarcoma. Cell Prolif. 2014; 48(1):1-6. PMC: 6496123. DOI: 10.1111/cpr.12160. View

Lv C, Bai Z, Liu Z, Luo P, Zhang J . MicroRNA-495 suppresses human renal cell carcinoma malignancy by targeting SATB1. Am J Transl Res. 2015; 7(10):1992-9. PMC: 4656775. View

Du J, Liu W, Jin T, Zhao Z, Bai R, Xue H . A single-nucleotide polymorphism in MMP9 is associated with decreased risk of steroid-induced osteonecrosis of the femoral head. Oncotarget. 2016; 7(42):68434-68441. PMC: 5356565. DOI: 10.18632/oncotarget.12034. View

Zhang S, Tang Q . Predicting protein subcellular localization based on information content of gene ontology terms. Comput Biol Chem. 2016; 65:1-7. DOI: 10.1016/j.compbiolchem.2016.09.009. View

Shan T, Ouyang H, Yu T, Li J, Huang C, Yang H . miRNA-30e regulates abnormal differentiation of small intestinal epithelial cells in diabetic mice by downregulating Dll4 expression. Cell Prolif. 2016; 49(1):102-14. PMC: 6496571. DOI: 10.1111/cpr.12230. View

Yu Z, Fan L, Li J, Ge Z, Dang X, Wang K . Lithium prevents rat steroid-related osteonecrosis of the femoral head by β-catenin activation. Endocrine. 2015; 52(2):380-90. DOI: 10.1007/s12020-015-0747-y. View

10.

Yamasaki K, Nakasa T, Miyaki S, Yamasaki T, Yasunaga Y, Ochi M . Angiogenic microRNA-210 is present in cells surrounding osteonecrosis. J Orthop Res. 2012; 30(8):1263-70. DOI: 10.1002/jor.22079. View

11.

Wu X, Zhang Y, Guo X, Xu H, Xu Z, Duan D . Identification of differentially expressed microRNAs involved in non-traumatic osteonecrosis through microRNA expression profiling. Gene. 2015; 565(1):22-9. DOI: 10.1016/j.gene.2015.03.072. View

12.

Chen L, Zhang Y, Zheng M, Huang T, Cai Y . Identification of compound-protein interactions through the analysis of gene ontology, KEGG enrichment for proteins and molecular fragments of compounds. Mol Genet Genomics. 2016; 291(6):2065-2079. DOI: 10.1007/s00438-016-1240-x. View

13.

Zhang Y, Yin J, Ding H, Zhang C, Gao Y . Vitamin K2 Ameliorates Damage of Blood Vessels by Glucocorticoid: a Potential Mechanism for Its Protective Effects in Glucocorticoid-induced Osteonecrosis of the Femoral Head in a Rat Model. Int J Biol Sci. 2016; 12(7):776-85. PMC: 4910597. DOI: 10.7150/ijbs.15248. View

14.

Li Z, Shen J, Chan M, Wu W . MicroRNA-379 suppresses osteosarcoma progression by targeting PDK1. J Cell Mol Med. 2016; 21(2):315-323. PMC: 5264134. DOI: 10.1111/jcmm.12966. View

15.

Li Z, Yu X, Shen J, Chan M, Wu W . MicroRNA in intervertebral disc degeneration. Cell Prolif. 2015; 48(3):278-83. PMC: 6496566. DOI: 10.1111/cpr.12180. View

16.

Yuan H, Zhang J, Guo C, Yan Z . Clinical outcomes of osteonecrosis of the femoral head after autologous bone marrow stem cell implantation: a meta-analysis of seven case-control studies. Clinics (Sao Paulo). 2016; 71(2):110-3. PMC: 4760366. DOI: 10.6061/clinics/2016(02)10. View

17.

Jing W, Jiang W . MicroRNA-93 regulates collagen loss by targeting MMP3 in human nucleus pulposus cells. Cell Prolif. 2015; 48(3):284-92. PMC: 6495943. DOI: 10.1111/cpr.12176. View

18.

Yuan H, Christina V, Guo C, Chu Y, Liu R, Yan Z . Involvement of MicroRNA-210 Demethylation in Steroid-associated Osteonecrosis of the Femoral Head. Sci Rep. 2016; 6:20046. PMC: 4726266. DOI: 10.1038/srep20046. View

19.

Lan C, Chen Q, Li J . Grouping miRNAs of similar functions via weighted information content of gene ontology. BMC Bioinformatics. 2017; 17(Suppl 19):507. PMC: 5260111. DOI: 10.1186/s12859-016-1367-0. View

20.

Chen L, Zhang Y, Zou Q, Chu C, Ji Z . Analysis of the chemical toxicity effects using the enrichment of Gene Ontology terms and KEGG pathways. Biochim Biophys Acta. 2016; 1860(11 Pt B):2619-26. DOI: 10.1016/j.bbagen.2016.05.015. View