Altered Microstructure of Brain White Matter in Females with Anorexia Nervosa: a Diffusion Tensor Imaging Study

Overview

Journal Neuropsychiatr Dis Treat

Publisher Dove Medical Press

Specialty Psychiatry

Date 2017 Dec 5

PMID 29200856

Citations 8

Authors

Shao-Hua Hu

Hong Feng

Ting-Ting Xu

Hao-Rong Zhang

Zhi-Yong Zhao

Jian-Bo Lai

Dong-Rong Xu

Yi Xu

Affiliations

Soon will be listed here.

Abstract

Objective: Structural studies have reported anorexia nervosa (AN) patients with abnormal gray matter in several brain regions and dysfunction in some connected neural circuits. However, the role of white matter (WM) in AN patients has rarely been investigated. The present study aimed to assess alterations in WM microstructure of the entire brain in females with AN using a voxel-based method on diffusion tensor imaging (DTI) data.

Materials And Methods: The study enrolled 8 female patients with AN and 14 age-matched females as controls (CW). The DTI data was collected from each subject to calculate the fractional anisotropy (FA) maps of the whole brain by the DTI-Studio software. Subsequently, a 2-sample -test (<0.05, corrected) was performed to detect the difference in FA maps of AN and CW group, and a Pearson's correlation analyzed the relationship between mean FA value of brain regions and body mass index (BMI).

Results: Compared with CW, AN patients revealed a significant decrease in FA maps in the left superior frontal gyrus, medial frontal gyrus, anterior cingulate cortex, middle frontal gyrus, inferior frontal gyrus, thalamus, and bilateral insula. Moreover, significantly positive correlations were established between the mean FA value of the left inferior frontal gyrus, insula as well as thalamus and BMI in AN patients.

Conclusions: Our findings supported the presence of WM abnormality in patients with AN. The significant differences of FA maps, in patients with AN, were associated with their aberrant BMI. The results further improved our understanding of the pathophysiological mechanisms underlying AN.

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References

Uher R, Brammer M, Murphy T, Campbell I, Ng V, Williams S . Recovery and chronicity in anorexia nervosa: brain activity associated with differential outcomes. Biol Psychiatry. 2003; 54(9):934-42. DOI: 10.1016/s0006-3223(03)00172-0. View

Muhlau M, Gaser C, Ilg R, Conrad B, Leibl C, Cebulla M . Gray matter decrease of the anterior cingulate cortex in anorexia nervosa. Am J Psychiatry. 2007; 164(12):1850-7. DOI: 10.1176/appi.ajp.2007.06111861. View

Miyake Y, Okamoto Y, Onoda K, Kurosaki M, Shirao N, Okamoto Y . Brain activation during the perception of distorted body images in eating disorders. Psychiatry Res. 2010; 181(3):183-92. DOI: 10.1016/j.pscychresns.2009.09.001. View

Paus T . Primate anterior cingulate cortex: where motor control, drive and cognition interface. Nat Rev Neurosci. 2001; 2(6):417-24. DOI: 10.1038/35077500. View

Holliday J, Tchanturia K, Landau S, Collier D, Treasure J . Is impaired set-shifting an endophenotype of anorexia nervosa?. Am J Psychiatry. 2005; 162(12):2269-75. DOI: 10.1176/appi.ajp.162.12.2269. View

Papadopoulos F, Ekbom A, Brandt L, Ekselius L . Excess mortality, causes of death and prognostic factors in anorexia nervosa. Br J Psychiatry. 2009; 194(1):10-7. DOI: 10.1192/bjp.bp.108.054742. View

Friederich H, Walther S, Bendszus M, Biller A, Thomann P, Zeigermann S . Grey matter abnormalities within cortico-limbic-striatal circuits in acute and weight-restored anorexia nervosa patients. Neuroimage. 2011; 59(2):1106-13. DOI: 10.1016/j.neuroimage.2011.09.042. View

Frank G, Shott M, Hagman J, Yang T . Localized brain volume and white matter integrity alterations in adolescent anorexia nervosa. J Am Acad Child Adolesc Psychiatry. 2013; 52(10):1066-1075.e5. PMC: 4082770. DOI: 10.1016/j.jaac.2013.07.007. View

Klump K, Strober M, Bulik C, Thornton L, Johnson C, Devlin B . Personality characteristics of women before and after recovery from an eating disorder. Psychol Med. 2005; 34(8):1407-18. DOI: 10.1017/s0033291704002442. View

10.

Frank G . Advances from neuroimaging studies in eating disorders. CNS Spectr. 2015; 20(4):391-400. PMC: 4989857. DOI: 10.1017/S1092852915000012. View

11.

Konstantakopoulos G, Varsou E, Dikeos D, Ioannidi N, Gonidakis F, Papadimitriou G . Delusionality of body image beliefs in eating disorders. Psychiatry Res. 2012; 200(2-3):482-8. DOI: 10.1016/j.psychres.2012.03.023. View

12.

Kazlouski D, Rollin M, Tregellas J, Shott M, Jappe L, Hagman J . Altered fimbria-fornix white matter integrity in anorexia nervosa predicts harm avoidance. Psychiatry Res. 2011; 192(2):109-16. PMC: 3085716. DOI: 10.1016/j.pscychresns.2010.12.006. View

13.

Via E, Zalesky A, Sanchez I, Forcano L, Harrison B, Pujol J . Disruption of brain white matter microstructure in women with anorexia nervosa. J Psychiatry Neurosci. 2014; 39(6):367-75. PMC: 4214871. DOI: 10.1503/jpn.130135. View

14.

Streitburger D, Moller H, Tittgemeyer M, Hund-Georgiadis M, Schroeter M, Mueller K . Investigating structural brain changes of dehydration using voxel-based morphometry. PLoS One. 2012; 7(8):e44195. PMC: 3430653. DOI: 10.1371/journal.pone.0044195. View

15.

Wagner A, Ruf M, Braus D, Schmidt M . Neuronal activity changes and body image distortion in anorexia nervosa. Neuroreport. 2003; 14(17):2193-7. DOI: 10.1097/00001756-200312020-00012. View

16.

Le Bihan D . Looking into the functional architecture of the brain with diffusion MRI. Nat Rev Neurosci. 2003; 4(6):469-80. DOI: 10.1038/nrn1119. View

17.

Brooks S, Barker G, ODaly O, Brammer M, Williams S, Benedict C . Restraint of appetite and reduced regional brain volumes in anorexia nervosa: a voxel-based morphometric study. BMC Psychiatry. 2011; 11:179. PMC: 3278387. DOI: 10.1186/1471-244X-11-179. View

18.

Pessoa L . How do emotion and motivation direct executive control?. Trends Cogn Sci. 2009; 13(4):160-6. PMC: 2773442. DOI: 10.1016/j.tics.2009.01.006. View

19.

Keating C . Theoretical perspective on anorexia nervosa: the conflict of reward. Neurosci Biobehav Rev. 2009; 34(1):73-9. DOI: 10.1016/j.neubiorev.2009.07.004. View

20.

Yucel M, Wood S, Fornito A, Riffkin J, Velakoulis D, Pantelis C . Anterior cingulate dysfunction: implications for psychiatric disorders?. J Psychiatry Neurosci. 2003; 28(5):350-4. PMC: 193981. View