Acute Lymphoblastic Leukemia As Secondary Malignancy in a Case of Ewing's Sarcoma on Treatment

Overview

Journal Indian J Med Paediatr Oncol

Publisher Thieme

Specialty Oncology

Date 2017 Dec 5

PMID 29200689

Citations 1

Authors

Satyam Satyarth

Sonia Parikh

Asha Anand

Jyoti Sawhney

Harsha Panchal

Apurva Patel

Sandeep Shah

Affiliations

Soon will be listed here.

Abstract

The survival of Ewing's sarcoma (ES) has improved due to advances in both local and systemic therapy. This has given rise to an increased detection of second malignant neoplasms which can be in the form of solid tumors and hematological malignancies. The most common hematological malignancies are acute myeloid leukemia/myelodysplastic syndrome. Acute lymphoblastic leukemia (ALL) is relatively uncommon in occurrence in this setting. Furthermore, the average refractory period for hematological malignancies varies from 3 to 5 years. We report a case of a young female who developed ALL while on adjuvant therapy for ES.

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References

Burdach S, van Kaick B, Laws H, Ahrens S, Haase R, Korholz D . Allogeneic and autologous stem-cell transplantation in advanced Ewing tumors. An update after long-term follow-up from two centers of the European Intergroup study EICESS. Stem-Cell Transplant Programs at Düsseldorf University Medical Center,.... Ann Oncol. 2001; 11(11):1451-62. DOI: 10.1023/a:1026539908115. View

Goldsby R, Burke C, Nagarajan R, Zhou T, Chen Z, Marina N . Second solid malignancies among children, adolescents, and young adults diagnosed with malignant bone tumors after 1976: follow-up of a Children's Oncology Group cohort. Cancer. 2008; 113(9):2597-604. PMC: 2765980. DOI: 10.1002/cncr.23860. View

Paulino A, Fowler B . Secondary neoplasms after radiotherapy for a childhood solid tumor. Pediatr Hematol Oncol. 2005; 22(2):89-101. DOI: 10.1080/08880010590896459. View

Wagner L, Neel M, Pappo A, Merchant T, Poquette C, Rao B . Fractures in pediatric Ewing sarcoma. J Pediatr Hematol Oncol. 2002; 23(9):568-71. DOI: 10.1097/00043426-200112000-00003. View

Bhatia S, Krailo M, Chen Z, Burden L, Askin F, Dickman P . Therapy-related myelodysplasia and acute myeloid leukemia after Ewing sarcoma and primitive neuroectodermal tumor of bone: A report from the Children's Oncology Group. Blood. 2006; 109(1):46-51. PMC: 1785079. DOI: 10.1182/blood-2006-01-023101. View

Spunt S, Rodriguez-Galindo C, Fuller C, Harper J, Krasin M, Billups C . Ewing sarcoma-family tumors that arise after treatment of primary childhood cancer. Cancer. 2006; 107(1):201-6. DOI: 10.1002/cncr.21962. View

Hawkins M, Wilson L, BURTON H, Potok M, Winter D, Marsden H . Radiotherapy, alkylating agents, and risk of bone cancer after childhood cancer. J Natl Cancer Inst. 1996; 88(5):270-8. DOI: 10.1093/jnci/88.5.270. View

Paulussen M, Ahrens S, Lehnert M, Taeger D, Hense H, Wagner A . Second malignancies after ewing tumor treatment in 690 patients from a cooperative German/Austrian/Dutch study. Ann Oncol. 2002; 12(11):1619-30. DOI: 10.1023/a:1013148730966. View

Ceha H, Balm A, de Jong D, van t Veer L . Multiple malignancies in a patient with bilateral retinoblastoma. J Laryngol Otol. 1998; 112(2):189-92. DOI: 10.1017/s0022215100140289. View

10.

Grier H, Krailo M, Tarbell N, Link M, Fryer C, Pritchard D . Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med. 2003; 348(8):694-701. DOI: 10.1056/NEJMoa020890. View

11.

Kuttesch Jr J, Wexler L, Marcus R, Fairclough D, White M, Mao L . Second malignancies after Ewing's sarcoma: radiation dose-dependency of secondary sarcomas. J Clin Oncol. 1996; 14(10):2818-25. DOI: 10.1200/JCO.1996.14.10.2818. View

12.

Sultan I, Rihani R, Hazin R, Rodriguez-Galindo C . Second malignancies in patients with Ewing Sarcoma Family of Tumors: A population-based study. Acta Oncol. 2010; 49(2):237-44. DOI: 10.3109/02841860903253538. View

13.

Cope J, Tsokos M, Miller R . Ewing sarcoma and sinonasal neuroectodermal tumors as second malignant tumors after retinoblastoma and other neoplasms. Med Pediatr Oncol. 2001; 36(2):290-4. DOI: 10.1002/1096-911X(20010201)36:2<290::AID-MPO1067>3.0.CO;2-5. View

14.

McLean T, Hertel C, Young M, Marcus K, Schizer M, Gebhardt M . Late events in pediatric patients with Ewing sarcoma/primitive neuroectodermal tumor of bone: the Dana-Farber Cancer Institute/Children's Hospital experience. J Pediatr Hematol Oncol. 1999; 21(6):486-93. View

15.

Bacci G, Toni A, Avella M, Manfrini M, Sudanese A, Ciaroni D . Long-term results in 144 localized Ewing's sarcoma patients treated with combined therapy. Cancer. 1989; 63(8):1477-86. DOI: 10.1002/1097-0142(19890415)63:8<1477::aid-cncr2820630805>3.0.co;2-8. View

16.

Mittal R, Al Awadi S, Sahar O, Behbehani A . Ewing's sarcoma as second malignant neoplasm after retinoblastoma: a case report. Med Princ Pract. 2007; 17(1):84-5. DOI: 10.1159/000109597. View

17.

Thirman M, Gill H, Burnett R, Mbangkollo D, McCabe N, Kobayashi H . Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations. N Engl J Med. 1993; 329(13):909-14. DOI: 10.1056/NEJM199309233291302. View

18.

Rossbach H, Chamizo W, Walling A, Grana N, Washington K, Barbosa J . Ki-1+ large-cell anaplastic lymphoma after Ewing sarcoma. J Pediatr Hematol Oncol. 1999; 21(1):50-2. View

19.

Fuchs B, Valenzuela R, Petersen I, Arndt C, Sim F . Ewing's sarcoma and the development of secondary malignancies. Clin Orthop Relat Res. 2003; (415):82-9. DOI: 10.1097/01.blo.0000093900.12372.e4. View

20.

Helton K, Fletcher B, Kun L, Jenkins 3rd J, Pratt C . Bone tumors other than osteosarcoma after retinoblastoma. Cancer. 1993; 71(9):2847-53. DOI: 10.1002/1097-0142(19930501)71:9<2847::aid-cncr2820710928>3.0.co;2-e. View