In Situ Characterization of Advanced Glycation End Products (AGEs) in Collagen and Model Extracellular Matrix by Solid State NMR

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2017 Dec 2

PMID 29192920

Citations 6

Authors

R Li

R Rajan

W C V Wong

D G Reid

M J Duer

V J Somovilla

N Martinez-Saez

G J L Bernardes

R Hayward

C M Shanahan

Affiliations

Soon will be listed here.

Abstract

Non-enzymatic glycation of extracellular matrix with (U-C)-d-ribose-5-phosphate (R5P), enables in situ 2D ssNMR identification of many deleterious protein modifications and crosslinks, including previously unreported oxalamido and hemiaminal (CH-CH(OH)NHR) substructures. Changes in charged residue proportions and distribution may be as important as crosslinking in provoking and understanding harmful tissue changes.

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