Israel Transcutaneous Bilirubin Nomogram Predicts Significant Hyperbilirubinemia

Overview

Journal J Perinatol

Specialty Gynecology & Obstetrics

Date 2017 Dec 2

PMID 29192695

Citations 5

Authors

R Bromiker

A GOLDBERG

M Kaplan

Affiliations

Soon will be listed here.

Abstract

Objective: We constructed a transcutaneous bilirubin (TcB) nomogram to represent major sectors of the Israeli population. We studied the risk of hyperbilirubinemia, defined as meeting the requirements for phototherapy, per percentile risk category.

Study Design: Newborns ⩾36 weeks gestation were tested daily for TcB, using Drager JM-103 devices, during birth hospitalization. A nomogram was constructed and divided into four risk groups and validated by calculating the need for phototherapy for each group.

Results: A total of 3303 measurements were performed on 1059 consecutive newborns including Ashkenazi, Sephardic and mixed Ashkenazi/Sephardic Jews, Arab and Ethiopian Jewish. Phototherapy risk increased progressively and more than 100-fold, from 0/225 in the <40th percentile group through 27/120 (22.5%) for those >95th percentile (relative risk (95% confidence interval) 102 (6 to 1669) for those >95th percentile compared with those <40th percentile). The optimal risk for discriminating the need for phototherapy was >75th percentile (sensitivity 93.33, specificity 59.47).

Conclusion: The risk of significant hyperbilirubinemia increased progressively with increasing percentile. Newborns >75th percentile groups are at high risk for phototherapy and should be closely monitored.

Citing Articles

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Transcutaneous bilirubin nomogram for evaluating the risk of hyperbilirubinemia in Iranian healthy newborns.

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References

De Luca D, Romagnoli C, Tiberi E, Zuppa A, Zecca E . Skin bilirubin nomogram for the first 96 h of life in a European normal healthy newborn population, obtained with multiwavelength transcutaneous bilirubinometry. Acta Paediatr. 2008; 97(2):146-50. DOI: 10.1111/j.1651-2227.2007.00622.x. View

Abu Omar R, Algur N, Megged O, Hammerman C, Kaplan M . Glucose-6-Phosphate Dehydrogenase Screening in Israel-Arab and Palestinian-Arab Neonates. J Pediatr. 2015; 167(1):169-72. DOI: 10.1016/j.jpeds.2015.04.039. View

Engle W, Lai S, Ahmad N, Manning M, Jackson G . An hour-specific nomogram for transcutaneous bilirubin values in term and late preterm Hispanic neonates. Am J Perinatol. 2009; 26(6):425-30. DOI: 10.1055/s-0029-1214238. View

Kaplan M, Merlob P, Regev R . Israel guidelines for the management of neonatal hyperbilirubinemia and prevention of kernicterus. J Perinatol. 2008; 28(6):389-97. DOI: 10.1038/jp.2008.20. View

Yu Z, Dong X, Han S, Chen Y, Qiu Y, Sha L . Transcutaneous bilirubin nomogram for predicting neonatal hyperbilirubinemia in healthy term and late-preterm Chinese infants. Eur J Pediatr. 2010; 170(2):185-91. DOI: 10.1007/s00431-010-1281-9. View

Bhutani V, Johnson L, Sivieri E . Predictive ability of a predischarge hour-specific serum bilirubin for subsequent significant hyperbilirubinemia in healthy term and near-term newborns. Pediatrics. 1999; 103(1):6-14. DOI: 10.1542/peds.103.1.6. View

Fouzas S, Mantagou L, Skylogianni E, Mantagos S, Varvarigou A . Transcutaneous bilirubin levels for the first 120 postnatal hours in healthy neonates. Pediatrics. 2009; 125(1):e52-7. DOI: 10.1542/peds.2009-0403. View

Raimondi F, Lama S, Landolfo F, Sellitto M, Borrelli A, Maffucci R . Measuring transcutaneous bilirubin: a comparative analysis of three devices on a multiracial population. BMC Pediatr. 2012; 12:70. PMC: 3445817. DOI: 10.1186/1471-2431-12-70. View

Olusanya B, Imosemi D, Emokpae A . Differences Between Transcutaneous and Serum Bilirubin Measurements in Black African Neonates. Pediatrics. 2016; 138(3). DOI: 10.1542/peds.2016-0907. View

10.

Riskin A, Tamir A, Kugelman A, Hemo M, Bader D . Is visual assessment of jaundice reliable as a screening tool to detect significant neonatal hyperbilirubinemia?. J Pediatr. 2008; 152(6):782-7, 787.e1-2. DOI: 10.1016/j.jpeds.2007.11.003. View

11.

Jeffrey Maisels M, Kring E . Transcutaneous bilirubin levels in the first 96 hours in a normal newborn population of > or = 35 weeks' gestation. Pediatrics. 2006; 117(4):1169-73. DOI: 10.1542/peds.2005-0744. View

12.

Akahira-Azuma M, Yonemoto N, Mori R, Hosokawa S, Matsushita T, Sukhbat K . An hour-specific transcutaneous bilirubin nomogram for Mongolian neonates. Eur J Pediatr. 2015; 174(10):1299-304. PMC: 4575357. DOI: 10.1007/s00431-015-2536-2. View

13.

Romagnoli C, Tiberi E, Barone G, De Curtis M, Regoli D, Paolillo P . Validation of transcutaneous bilirubin nomogram in identifying neonates not at risk of hyperbilirubinaemia: a prospective, observational, multicenter study. Early Hum Dev. 2011; 88(1):51-5. DOI: 10.1016/j.earlhumdev.2011.07.001. View

14.

Bental Y, Shiff Y, Dorsht N, Litig E, Tuval L, Mimouni F . Bhutani-based nomograms for the prediction of significant hyperbilirubinaemia using transcutaneous measurements of bilirubin. Acta Paediatr. 2009; 98(12):1902-8. DOI: 10.1111/j.1651-2227.2009.01385.x. View

15.

Kaplan M, Bromiker R, Hammerman C . Hyperbilirubinemia, hemolysis, and increased bilirubin neurotoxicity. Semin Perinatol. 2014; 38(7):429-37. DOI: 10.1053/j.semperi.2014.08.006. View

16.

Kuboi T, Kusaka T, Kawada K, Koyano K, Nakamura S, Okubo K . Hour-specific nomogram for transcutaneous bilirubin in Japanese neonates. Pediatr Int. 2013; 55(5):608-11. DOI: 10.1111/ped.12149. View

17.

Draque C, Sanudo A, de Araujo Peres C, Almeida M . Transcutaneous bilirubin in exclusively breastfed healthy term newborns up to 12 days of life. Pediatrics. 2011; 128(3):e565-71. DOI: 10.1542/peds.2010-3878. View

18.

Mohamed I, Blanchard A, Delvin E, Cousineau J, Carceller A . Plotting transcutaneous bilirubin measurements on specific transcutaneous nomogram results in better prediction of significant hyperbilirubinemia in healthy term and near-term newborns: a pilot study. Neonatology. 2014; 105(4):306-11. DOI: 10.1159/000358373. View

19.

. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2004; 114(1):297-316. DOI: 10.1542/peds.114.1.297. View

20.

Han S, Yu Z, Liu L, Wang J, Wei Q, Jiang C . A Model for Predicting Significant Hyperbilirubinemia in Neonates From China. Pediatrics. 2015; 136(4):e896-905. DOI: 10.1542/peds.2014-4058. View