LONGITUDINAL CHANGES IN THE OPTIC NERVE HEAD AND RETINA OVER TIME IN VERY YOUNG CHILDREN WITH FAMILIAL EXUDATIVE VITREORETINOPATHY

Overview

Journal Retina

Date 2017 Dec 1

PMID 29190238

Citations 7

Authors

Jonghyun Lee

Mays A El-Dairi

Du Tran-Viet

Shwetha Mangalesh

Alexandria Dandridge

Kim Jiramongkolchai

Christian Viehland

Cynthia A Toth

Affiliations

Soon will be listed here.

Abstract

Purpose: To explore vitreoretinal pathologies and their longitudinal changes visible on handheld optical coherence tomography (OCT) of young children with familial exudative vitreoretinopathy.

Methods: The authors retrospectively analyzed handheld OCT images for vitreoretinal interface and retinal abnormalities and optic nerve head (ONH) elevation.

Results: From 26 eyes of 16 children (mean age 32 months) with familial exudative vitreoretinopathy, 10 had ONH dragging on photographs, and in these, handheld OCT revealed temporal and anterior retinal displacement, prominent vitreopapillary adhesion or traction, and retinal nerve fiber layer thickening at ONH margins with adjacent retinal elevation. Despite a nearly normal photographic appearance, handheld OCT revealed ONH elevation with vitreopapillary traction (6/16 eyes), ONH edema (1/16 eye), and retinal vascular protrusion (5/16 eyes). Handheld OCT-visualized vitreous abnormalities (18/26 eyes) were more prevalent at higher stages of disease. Handheld OCT-visualized elevation of ONH and the retina worsened over time in nine eyes and improved in 5/6 eyes after vitrectomy.

Conclusion: Handheld OCT can detect early ONH, retinal, and vitreous changes in eyes with familial exudative vitreoretinopathy. Contraction of strongly adherent vitreous in young patients with familial exudative vitreoretinopathy appears to cause characteristic ONH dragging and tractional complications without partial posterior vitreous detachment. Vitreopapillary dragging may be visible only on OCT and may progress in the absence of obvious retinal change on conventional examination.

Citing Articles

Preterm infant retinal OCT markers of perinatal health and retinopathy of prematurity.

Mangalesh S, Toth C Front Pediatr. 2023; 11:1238193.

PMID: 37808559 PMC: 10551634. DOI: 10.3389/fped.2023.1238193.

Vessels characteristics in familial exudative vitreoretinopathy and retinopathy of prematurity based on deep convolutional neural networks.

Deng X, Chen K, Chen Y, Xiang Z, Zhang S, Shen L Front Pediatr. 2023; 11:1252875.

PMID: 37691773 PMC: 10484092. DOI: 10.3389/fped.2023.1252875.

Peripheral and central retinal vascular changes in asymptomatic family members of patients with familial exudative vitreoretinopathy.

Ozdek S, Tefon Aribas A, Atalay H Graefes Arch Clin Exp Ophthalmol. 2023; 261(12):3449-3456.

PMID: 37581650 DOI: 10.1007/s00417-023-06184-0.

Optical Coherence Tomography and Optical Coherence Tomography Angiography in Pediatric Retinal Diseases.

Wang C, Chang Y, Tan G, Lee S, Paul Chan R, Wu W Diagnostics (Basel). 2023; 13(8).

PMID: 37189561 PMC: 10138206. DOI: 10.3390/diagnostics13081461.

Clinical characteristics and mutation spectrum in 33 Chinese families with familial exudative vitreoretinopathy.

Mao J, Chen Y, Fang Y, Shao Y, Xiang Z, Li H Ann Med. 2022; 54(1):3286-3298.

PMID: 36411543 PMC: 9704097. DOI: 10.1080/07853890.2022.2146744.

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