Dietary Sugar Intake Was Associated with Increased Body Fatness but Decreased Cardiovascular Mortality in Chinese Elderly: an 11-year Prospective Study of Mr and Ms OS of Hong Kong

Overview

Journal Int J Obes (Lond)

Specialty Endocrinology

Date 2017 Dec 1

PMID 29188817

Citations 13

Authors

Z-M Liu

L A Tse

D Chan

C Wong

S Y S Wong

Affiliations

Soon will be listed here.

Abstract

Background/objectives: Epidemiological studies suggest that sugar intake contributes to weight gain and increased risk of cardiovascular diseases (CVDs). However, this association is largely undefined in the elderly population. Our aim was to investigate the effect of sugar consumption on the subsequent changes in body fatness and CVD mortality in Chinese elderly.

Methods: A total of 2000 men and 2000 women aged ⩾65 years were recruited from 2001 to 2003. Dietary sugar intake was estimated based on a validated 329-item food frequency questionnaire and a local sugar database. Adiposity was measured using dual-energy X-ray absorptiometry at baseline and follow-up after 4 years. Mortality was ascertained by local death registry until March 2014. Multivariable linear and Cox regression were conducted to evaluate the association of sugar consumption on the changes in body fatness and CVD mortality.

Results: A total of 174 CVD deaths were documented within the total 37 999 person-years' follow-up. Significant positive association between sugar intake and increase in body fatness at follow-up after 4 years was found in men but not in women. After adjustment for potential confounders, men who consumed 1% increase in added sugar had an increase in whole body fat by 0.043 kg (P=0.006), central fat by 0.029 kg (P=0.016) and peripheral fat by 0.026 kg (P=0.006). However, in both genders, after an average of 11.1-year follow-up, compared with the lowest quintile, the highest intakes of added sugar were associated with significantly lowered CVD mortality by 74.9% (hazard ratio (HR) (95% confidence interval (CI)): 0.251(0.070, 0.899)) in a dose-response manner (P=0.011). This association was attenuated to non-significance by further adjustment of the change in body fatness (P=0.055).

Conclusions: Thus higher sugar intake of the Chinese elderly was associated with increased adiposity in men but decreased CVD mortality. The current World Health Organization recommendation for the elderly should be reviewed.

Citing Articles

Charting the Chronology of Research on Added Sugars: A Scoping Review and Evidence Map.

Fleming S, Peregoy J, Paul T, Scott M, Gaine P Nutrients. 2023; 15(23).

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Added Sugar, Sugar-Sweetened Beverages, and Artificially Sweetened Beverages and Risk of Cardiovascular Disease: Findings from the Women's Health Initiative and a Network Meta-Analysis of Prospective Studies.

Yang B, Glenn A, Liu Q, Madsen T, Allison M, Shikany J Nutrients. 2022; 14(20).

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Joint Associations of Food Groups with All-Cause and Cause-Specific Mortality in the Mr. OS and Ms. OS Study: A Prospective Cohort.

Yang J, Yang A, Yeung S, Woo J, Lo K Nutrients. 2022; 14(19).

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Association of added sugar intake with all-cause and cardiovascular disease mortality: a systematic review of cohort studies.

Song S, Shim J, Song Y Nutr Res Pract. 2022; 16(Suppl 1):S21-S36.

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A Scoping Review of Epidemiological Studies on Intake of Sugars in Geographically Dispersed Asian Countries: Comparison of Dietary Assessment Methodology.

Fujiwara A, Omura Y, Oono F, Sugimoto M, Sasaki S, Takimoto H Adv Nutr. 2022; 13(5):1947-1973.

PMID: 35641021 PMC: 9526866. DOI: 10.1093/advances/nmac061.

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