Therapeutic Prospects of MicroRNAs in Cancer Treatment Through Nanotechnology

Overview

Journal Drug Deliv Transl Res

Publisher Springer

Specialty Pharmacology

Date 2017 Nov 30

PMID 29185148

Citations 17

Authors

Rajendra Awasthi

Michael John Rathbone

Philip Michael Hansbro

Mary Bebawy

Kamal Dua

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) represent a new class of diagnostic and prognostic biomarker as well as new therapeutic targets in cancer therapy. miRNAs are gaining significant interest due to extensive advancements in knowledge since their discovery and, more recently, their translational application as therapeutic moieties and targets in the management of disease. miRNAs used in the treatment of cancer would position them as a new class of emerging therapeutic agents. Indeed, numerous candidate miRNAs have been identified as having therapeutic application in the treatment of cancer, but there is still much to learn about how to transform these into effective, patient-compliant, and targeted drug delivery systems. In this mini review, we discuss the utility and potential of nanotechnology in miRNA formulation and delivery with particular emphasis on cancer, including their role in conferring multidrug resistance and metastatic capacity. This review benefits both the formulation and biological scientists in understanding and exploring the new vistas of miRNA delivery using nanotechnology in the cancer clinically.

Citing Articles

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Yang H, He C, Feng Y, Jin J Oncol Lett. 2023; 27(1):24.

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Zhang S, Pang S, Pei W, Zhu H, Shi Y, Liu Z ACS Omega. 2023; 8(21):18435-18448.

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