Gelsolin Regulates Proliferation, Apoptosis and Invasion in Natural Killer/T-cell Lymphoma Cells

Overview

Journal Biol Open

Specialty Biology

Date 2017 Nov 28

PMID 29175858

Citations 6

Authors

Yanwei Guo

Hongqiao Zhang

Xin Xing

Lijuan Wang

Jian Zhang

Lin Yan

Xiaoke Zheng

Mingzhi Zhang

Affiliations

Soon will be listed here.

Abstract

The expression of gelsolin (GSN) is abnormal in many cancers, including extranodal nasal-type natural killer/T-cell lymphoma (NKTCL). However, the biological function of GSN and its mechanism in NKTCL remain unclear. We found that GSN overexpression significantly suppressed cell proliferation, colony formation and invasion, and promoted apoptosis of natural killer (NK) cell line YTS. Moreover, the upregulation of GSN significantly decreased the levels of PI3K and p-Akt. Interestingly, blocking the PI3K/Akt signaling pathway significantly inhibited cell proliferation and invasion and promoted apoptosis of YTS cells. In conclusion, our findings indicate that GSN can suppress cell proliferation and invasion and promote apoptosis of YTS cells, and the PI3K/Akt signaling pathway is likely to be involved in this process.

Citing Articles

Plasma Gelsolin Inhibits Natural Killer Cell Function and Confers Chemoresistance in Epithelial Ovarian Cancer.

Onuma T, Asare-Werehene M, Fujita Y, Yoshida Y, Tsang B Cells. 2024; 13(11.

PMID: 38891037 PMC: 11171658. DOI: 10.3390/cells13110905.

Changes of Ex Vivo Cervical Epithelial Cells Due to Electroporation with JMY.

Halasz H, Szatmari Z, Kovacs K, Koppan M, Papp S, Szabo-Meleg E Int J Mol Sci. 2023; 24(23).

PMID: 38069185 PMC: 10706833. DOI: 10.3390/ijms242316863.

Exosomal Plasma Gelsolin Is an Immunosuppressive Mediator in the Ovarian Tumor Microenvironment and a Determinant of Chemoresistance.

Onuma T, Asare-Werehene M, Yoshida Y, Tsang B Cells. 2022; 11(20).

PMID: 36291171 PMC: 9600545. DOI: 10.3390/cells11203305.

The p53 and Calcium Regulated Actin Rearrangement in Model Cells.

Hencz A, Szabo-Meleg E, Dayo M, Bilibani A, Barko S, Nyitrai M Int J Mol Sci. 2022; 23(16).

PMID: 36012344 PMC: 9408879. DOI: 10.3390/ijms23169078.

Plasma Gelsolin Confers Chemoresistance in Ovarian Cancer by Resetting the Relative Abundance and Function of Macrophage Subtypes.

Asare-Werehene M, Tsuyoshi H, Zhang H, Salehi R, Chang C, Carmona E Cancers (Basel). 2022; 14(4).

PMID: 35205790 PMC: 8870487. DOI: 10.3390/cancers14041039.

References

Deng R, Hao J, Han W, Ni Y, Huang X, Hu Q . Gelsolin regulates proliferation, apoptosis, migration and invasion in human oral carcinoma cells. Oncol Lett. 2015; 9(5):2129-2134. PMC: 4467278. DOI: 10.3892/ol.2015.3002. View

Li W, Yang M, Hong X, Dong T, Yi T, Lin S . Overexpression of gelsolin reduces the proliferation and invasion of colon carcinoma cells. Mol Med Rep. 2016; 14(4):3059-65. PMC: 5042772. DOI: 10.3892/mmr.2016.5652. View

Abedini M, Wang P, Huang Y, Cao M, Chou C, Shieh D . Cell fate regulation by gelsolin in human gynecologic cancers. Proc Natl Acad Sci U S A. 2014; 111(40):14442-7. PMC: 4209992. DOI: 10.1073/pnas.1401166111. View

Harabuchi Y, Imai S, Wakashima J, Hirao M, KATAURA A, OSATO T . Nasal T-cell lymphoma causally associated with Epstein-Barr virus: clinicopathologic, phenotypic, and genotypic studies. Cancer. 1996; 77(10):2137-49. DOI: 10.1002/(SICI)1097-0142(19960515)77:10<2137::AID-CNCR27>3.0.CO;2-V. View

Zhu X, Cai L, Meng Q, Jin X . Gelsolin inhibits the proliferation and invasion of the 786-0 clear cell renal cell carcinoma cell line in vitro. Mol Med Rep. 2015; 12(5):6887-94. DOI: 10.3892/mmr.2015.4313. View

Suzuki R, Suzumiya J, Yamaguchi M, Nakamura S, Kameoka J, Kojima H . Prognostic factors for mature natural killer (NK) cell neoplasms: aggressive NK cell leukemia and extranodal NK cell lymphoma, nasal type. Ann Oncol. 2009; 21(5):1032-40. DOI: 10.1093/annonc/mdp418. View

Blume-Jensen P, Hunter T . Oncogenic kinase signalling. Nature. 2001; 411(6835):355-65. DOI: 10.1038/35077225. View

Bellacosa A, De Feo D, Godwin A, BELL D, Cheng J, Altomare D . Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas. Int J Cancer. 1995; 64(4):280-5. DOI: 10.1002/ijc.2910640412. View

Li G, Arora P, Chen Y, McCulloch C, Liu P . Multifunctional roles of gelsolin in health and diseases. Med Res Rev. 2012; 32(5):999-1025. DOI: 10.1002/med.20231. View

10.

Vivanco I, Sawyers C . The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer. 2002; 2(7):489-501. DOI: 10.1038/nrc839. View

11.

Singh S, Chauhan A, Murakami N, Chauhan V . Profilin and gelsolin stimulate phosphatidylinositol 3-kinase activity. Biochemistry. 1996; 35(51):16544-9. DOI: 10.1021/bi9609634. View

12.

Fowles J, Denton C, Gustafson D . Comparative analysis of MAPK and PI3K/AKT pathway activation and inhibition in human and canine melanoma. Vet Comp Oncol. 2013; 13(3):288-304. DOI: 10.1111/vco.12044. View

13.

Staal S . Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. Proc Natl Acad Sci U S A. 1987; 84(14):5034-7. PMC: 305241. DOI: 10.1073/pnas.84.14.5034. View

14.

Yamaguchi M, Kwong Y, Kim W, Maeda Y, Hashimoto C, Suh C . Phase II study of SMILE chemotherapy for newly diagnosed stage IV, relapsed, or refractory extranodal natural killer (NK)/T-cell lymphoma, nasal type: the NK-Cell Tumor Study Group study. J Clin Oncol. 2011; 29(33):4410-6. DOI: 10.1200/JCO.2011.35.6287. View

15.

Ludvigsen M, Madsen C, Kamper P, Hamilton-Dutoit S, Bendix K, DAmore F . Histologically transformed follicular lymphoma exhibits protein profiles different from both non-transformed follicular and de novo diffuse large B-cell lymphoma. Blood Cancer J. 2015; 5:e293. PMC: 4382659. DOI: 10.1038/bcj.2015.18. View

16.

Takeuchi M, Sato Y, Yoshino T . [The frequency of malignant lymphoma subtypes based on World Health Organization (WHO) classification]. Nihon Rinsho. 2014; 72(3):436-40. View

17.

Jaccard A, Gachard N, Marin B, Rogez S, Audrain M, Suarez F . Efficacy of L-asparaginase with methotrexate and dexamethasone (AspaMetDex regimen) in patients with refractory or relapsing extranodal NK/T-cell lymphoma, a phase 2 study. Blood. 2010; 117(6):1834-9. DOI: 10.1182/blood-2010-09-307454. View

18.

Warfel N, Kraft A . PIM kinase (and Akt) biology and signaling in tumors. Pharmacol Ther. 2015; 151:41-9. PMC: 4957637. DOI: 10.1016/j.pharmthera.2015.03.001. View

19.

Liu J, Ji X, Li Z, Zheng H, Zheng W, Jia J . Nestin overexpression promotes the embryonic development of heart and brain through the regulation of cell proliferation. Brain Res. 2015; 1610:1-11. DOI: 10.1016/j.brainres.2015.03.044. View

20.

Zhuo J, Tan E, Yan B, Tochhawng L, Jayapal M, Koh S . Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade. PLoS One. 2012; 7(8):e43594. PMC: 3424201. DOI: 10.1371/journal.pone.0043594. View