The Lys469glu/K469E Polymorphism of the Inflammatory Gene Intercellular Adhesion Molecule-1 Lacks Any Apparent Role in the Polycystic Ovary Syndrome in Kashmiri Women: A Case Control Study

Overview

Journal Asian Pac J Cancer Prev

Specialty Oncology

Date 2017 Nov 28

PMID 29172260

Citations 2

Authors

Syed Douhath Yousuf

Mohammad Ashraf Ganie

Mohammad Afzal Zargar

Shajr Ul Amin

Gulzar A Bhat

Akbar Masood

Fouzia Rashid

Affiliations

Soon will be listed here.

Abstract

Background: Polycystic ovary syndrome (PCOS), associated with a state of low grade chronic inflammation, depends on multiple genetic and environmental factors. Elevated levels of inflammatory markers including intercellular adhesion molecule-1 (ICAM-1) have been demonstrated in affected women. Recent evidence indicates a significant linkage between chromosome 19p13 loci and multifactorial diseases that have an inflammatory component. The aim of this study was to assess the possible association of the lys469glu (K469E) polymorphism of the ICAM-1 gene located on chromosome 19p13 with risk of PCOS in Kashmiri women. Material and Methods: The K469E single nucleotide polymorphism (SNP) was analysed with DNA from peripheral blood leukocytes of 220 PCOS cases and 220 age matched non-PCOS healthy controls using PCR-RFLP. Results: Genotypic frequencies in cases were found to be 32 (14.5%) for EE, 98 (44.5%) for KE, and 90 (40.9%) for KK, with 130 (59.1%) for the KE+EE genotypes compared to healthy control values of 29 (13.2%) for EE, 113 (51.4%) for KE, 78 (35. 5%) for KK and 142 (64.5%) for KE+EE combined.The odds ratios for the EE, KE and KE:EE genotypes were 0.95(95% CI= 0.53-1.71)[p= 0.88], 0.75(95% CI= 0.50-1.12)[p =0.168] and 0.79 (95% CI =0.53-1.16) [p = 0.23], no statistically significant differences being found between cases and controls (χ2 =2.07; p=0.35). Conclusion: In conclusion, there was no apparent significant influence of the K469E polymorphism on risk of PCOS, or any clinical or laboratory parameters.

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References

Petrovic M, Osredkar J, Saraga-Babic M, Petrovic D . K469E polymorphism of the intracellular adhesion molecule 1 gene is associated with proliferative diabetic retinopathy in Caucasians with type 2 diabetes. Clin Exp Ophthalmol. 2008; 36(5):468-72. DOI: 10.1111/j.1442-9071.2008.01785.x. View

Blankenberg S, Barbaux S, Tiret L . Adhesion molecules and atherosclerosis. Atherosclerosis. 2003; 170(2):191-203. DOI: 10.1016/s0021-9150(03)00097-2. View

Papa A, Danese S, Urgesi R, Grillo A, Guglielmo S, Roberto I . Intercellular adhesion molecule 1 gene polymorphisms in inflammatory bowel disease. Eur Rev Med Pharmacol Sci. 2005; 8(5):187-91. View

Mycko M, Kwinkowski M, Tronczynska E, Szymanska B, Selmaj K . Multiple sclerosis: the increased frequency of the ICAM-1 exon 6 gene point mutation genetic type K469. Ann Neurol. 1998; 44(1):70-5. DOI: 10.1002/ana.410440113. View

Vinita K, Sripriya S, Prathiba K, Vaitheeswaran K, Sathyabaarathi R, Rajesh M . ICAM-1 K469E polymorphism is a genetic determinant for the clinical risk factors of T2D subjects with retinopathy in Indians: a population-based case-control study. BMJ Open. 2012; 2(4). PMC: 3425905. DOI: 10.1136/bmjopen-2012-001036. View

Lee E, Oh B, Lee J, Kimm K, Park J, Baek K . Association study between single nucleotide polymorphisms in the VEGF gene and polycystic ovary syndrome. Fertil Steril. 2007; 89(6):1751-9. DOI: 10.1016/j.fertnstert.2007.06.049. View

Vora D, Rosenbloom C, Beaudet A, Cottingham R . Polymorphisms and linkage analysis for ICAM-1 and the selectin gene cluster. Genomics. 1994; 21(3):473-7. DOI: 10.1006/geno.1994.1303. View

Marciniak A, Nawrocka Rutkowska J, Brodowska A, Wisniewska B, Starczewski A . Cardiovascular system diseases in patients with polycystic ovary syndrome - the role of inflammation process in this pathology and possibility of early diagnosis and prevention. Ann Agric Environ Med. 2016; 23(4):537-541. DOI: 10.5604/12321966.1226842. View

Nishimura M, Obayashi H, Maruya E, Ohta M, Tegoshi H, Fukui M . Association between type 1 diabetes age-at-onset and intercellular adhesion molecule-1 (ICAM-1) gene polymorphism. Hum Immunol. 2000; 61(5):507-10. DOI: 10.1016/s0198-8859(00)00101-4. View

10.

Chou C, Ueng K, Liu Y, Wu C, Yang S, Wang P . Impact of Intercellular Adhesion Molecule-1 Genetic Polymorphisms on Coronary Artery Disease Susceptibility in Taiwanese Subjects. Int J Med Sci. 2015; 12(6):510-6. PMC: 4466516. DOI: 10.7150/ijms.12097. View

11.

Nasiek M, Kos-Kudla B, Ostrowska Z, Marek B, Kajdaniuk D, Sieminska L . Plasma concentration of soluble intercellular adhesion molecule-1 in women with polycystic ovary syndrome. Gynecol Endocrinol. 2005; 19(4):208-15. DOI: 10.1080/09513590400014313. View

12.

Mohamed A, Rashed L, Amin H, Abu-Farha M, El Fadl S, Pakhoum S . K469E polymorphism of the intercellular adhesion molecule-1 gene in Egyptians with coronary heart disease. Ann Saudi Med. 2010; 30(6):432-6. PMC: 2994157. DOI: 10.4103/0256-4947.71061. View

13.

Vural P, Kanmaz-Ozer M, Dogru-Abbasoglu S, Gedikbasi A, Cil E, Karadag B . Lack of association between intercellular adhesion molecule-1 (ICAM-1) polymorphisms and polycystic ovary syndrome. J Assist Reprod Genet. 2011; 28(9):869-75. PMC: 3169688. DOI: 10.1007/s10815-011-9607-8. View

14.

Nejentsev S, Laine A, Simell O, Ilonen J . Intercellular adhesion molecule-1 (ICAM-1) K469E polymorphism: no association with type 1 diabetes among Finns. Tissue Antigens. 2000; 55(6):568-70. DOI: 10.1034/j.1399-0039.2000.550608.x. View

15.

Dimitriadis G, Kyrou I, Randeva H . Polycystic Ovary Syndrome as a Proinflammatory State: The Role of Adipokines. Curr Pharm Des. 2016; 22(36):5535-5546. DOI: 10.2174/1381612822666160726103133. View

16.

Kristiansen O, Nolsoe R, Holst H, Reker S, Larsen Z, Johannesen J . The intercellular adhesion molecule-1 K469E polymorphism in type 1 diabetes. Immunogenetics. 2000; 52(1-2):107-11. DOI: 10.1007/s002510000258. View

17.

Azziz R, Woods K, Reyna R, Key T, Knochenhauer E, Yildiz B . The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab. 2004; 89(6):2745-9. DOI: 10.1210/jc.2003-032046. View

18.

Kanmaz-Ozer M, Vural P, Dogru-Abbasoglu S, Gedikbasi A, Cil E, Karadag B . Polymorphisms of vascular cell adhesion molecule1 (VCAM1) in polycystic ovary syndrome determined by quantitative real-time polymerase chain reaction and melting curve analysis. Eur J Obstet Gynecol Reprod Biol. 2011; 160(2):174-8. DOI: 10.1016/j.ejogrb.2011.11.013. View

19.

Verity D, Vaughan R, Kondeatis E, Madanat W, Zureikat H, Fayyad F . Intercellular adhesion molecule-1 gene polymorphisms in Behçet's disease. Eur J Immunogenet. 2000; 27(2):73-6. DOI: 10.1046/j.1365-2370.2000.00202.x. View

20.

Iwao M, Morisaki H, Morisaki T . Single-nucleotide polymorphism g.1548G > A (E469K) in human ICAM-1 gene affects mRNA splicing pattern and TPA-induced apoptosis. Biochem Biophys Res Commun. 2004; 317(3):729-35. DOI: 10.1016/j.bbrc.2004.03.101. View