Haem-iron Plays a Key Role in the Regulation of the Ess/type VII Secretion System of Staphylococcus Aureus RN6390

Overview

Journal Microbiology (Reading)

Specialty Microbiology

Date 2017 Nov 25

PMID 29171824

Citations 10

Authors

M Guillermina Casabona

Holger Kneuper

Daniela Alferes De Lima

Catriona P Harkins

Martin Zoltner

Erik Hjerde

Matthew T G Holden

Tracy Palmer

Affiliations

Soon will be listed here.

Abstract

The Staphylococcus aureus type VII protein secretion system (T7SS) plays important roles in virulence and intra-species competition. Here we show that the T7SS in strain RN6390 is activated by supplementing the growth medium with haemoglobin, and its cofactor haemin (haem B). Transcript analysis and secretion assays suggest that activation by haemin occurs at a transcriptional and a post-translational level. Loss of T7 secretion activity by deletion of essC results in upregulation of genes required for iron acquisition. Taken together these findings suggest that the T7SS plays a role in iron homeostasis in at least some S. aureus strains.

Citing Articles

High-throughput functional analysis provides novel insight into type VII secretion in .

Yang Y, Scott A, Kneuper H, Alcock F, Palmer T Open Biol. 2024; 14(8):240060.

PMID: 39139050 PMC: 11322744. DOI: 10.1098/rsob.240060.

Microbial collaborations and conflicts: unraveling interactions in the gut ecosystem.

Wang S, Mu L, Yu C, He Y, Hu X, Jiao Y Gut Microbes. 2023; 16(1):2296603.

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Interbacterial competition mediated by the type VIIb secretion system.

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Type VII secretion systems: structure, functions and transport models.

Rivera-Calzada A, Famelis N, Llorca O, Geibel S Nat Rev Microbiol. 2021; 19(9):567-584.

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Activation of a bacterial killing machine.

Alcock F, Palmer T PLoS Genet. 2021; 17(1):e1009261.

PMID: 33411752 PMC: 7790229. DOI: 10.1371/journal.pgen.1009261.

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