Myostatin and Beyond in Cirrhosis: All Roads Lead to Sarcopenia

Overview

Journal J Cachexia Sarcopenia Muscle

Date 2017 Nov 24

PMID 29168629

Citations 36

Authors

Srinivasan Dasarathy

Affiliations

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References

Qiu J, Thapaliya S, Runkana A, Yang Y, Tsien C, Mohan M . Hyperammonemia in cirrhosis induces transcriptional regulation of myostatin by an NF-κB-mediated mechanism. Proc Natl Acad Sci U S A. 2013; 110(45):18162-7. PMC: 3831479. DOI: 10.1073/pnas.1317049110. View

Tsien C, Davuluri G, Singh D, Allawy A, Ten Have G, Thapaliya S . Metabolic and molecular responses to leucine-enriched branched chain amino acid supplementation in the skeletal muscle of alcoholic cirrhosis. Hepatology. 2015; 61(6):2018-29. PMC: 4441611. DOI: 10.1002/hep.27717. View

Dunn M, Josbeno D, Tevar A, Rachakonda V, Ganesh S, Schmotzer A . Frailty as Tested by Gait Speed is an Independent Risk Factor for Cirrhosis Complications that Require Hospitalization. Am J Gastroenterol. 2016; 111(12):1768-1775. DOI: 10.1038/ajg.2016.336. View

Lai J, Covinsky K, Dodge J, Boscardin W, Segev D, Roberts J . Development of a novel frailty index to predict mortality in patients with end-stage liver disease. Hepatology. 2017; 66(2):564-574. PMC: 5519430. DOI: 10.1002/hep.29219. View

Murphy K, Chee A, Gleeson B, Naim T, Swiderski K, Koopman R . Antibody-directed myostatin inhibition enhances muscle mass and function in tumor-bearing mice. Am J Physiol Regul Integr Comp Physiol. 2011; 301(3):R716-26. DOI: 10.1152/ajpregu.00121.2011. View

Zhang L, Pan J, Dong Y, Tweardy D, Dong Y, Garibotto G . Stat3 activation links a C/EBPδ to myostatin pathway to stimulate loss of muscle mass. Cell Metab. 2013; 18(3):368-79. PMC: 3794464. DOI: 10.1016/j.cmet.2013.07.012. View

McPherron A, Lawler A, Lee S . Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature. 1997; 387(6628):83-90. DOI: 10.1038/387083a0. View

Young V . Adult amino acid requirements: the case for a major revision in current recommendations. J Nutr. 1994; 124(8 Suppl):1517S-1523S. DOI: 10.1093/jn/124.suppl_8.1517S. View

Hayashi M, Ohnishi H, KAWADE Y, Muto Y, Takahashi Y . Augmented utilization of branched-chain amino acids by skeletal muscle in decompensated liver cirrhosis in special relation to ammonia detoxication. Gastroenterol Jpn. 1981; 16(1):64-70. DOI: 10.1007/BF02820426. View

10.

Kumar A, Davuluri G, Nascimento E Silva R, Engelen M, Ten Have G, Prayson R . Ammonia lowering reverses sarcopenia of cirrhosis by restoring skeletal muscle proteostasis. Hepatology. 2017; 65(6):2045-2058. PMC: 5444955. DOI: 10.1002/hep.29107. View

11.

Steelman C, Recknor J, Nettleton D, Reecy J . Transcriptional profiling of myostatin-knockout mice implicates Wnt signaling in postnatal skeletal muscle growth and hypertrophy. FASEB J. 2006; 20(3):580-2. DOI: 10.1096/fj.05-5125fje. View

12.

Bernardi H, Gay S, Fedon Y, Vernus B, Bonnieu A, Bacou F . Wnt4 activates the canonical β-catenin pathway and regulates negatively myostatin: functional implication in myogenesis. Am J Physiol Cell Physiol. 2011; 300(5):C1122-38. DOI: 10.1152/ajpcell.00214.2010. View

13.

Wang B, Wu G, Zhou Z, Dai Z, Sun Y, Ji Y . Glutamine and intestinal barrier function. Amino Acids. 2014; 47(10):2143-54. DOI: 10.1007/s00726-014-1773-4. View

14.

Mates J, Segura J, Campos-Sandoval J, Lobo C, Alonso L, Alonso F . Glutamine homeostasis and mitochondrial dynamics. Int J Biochem Cell Biol. 2009; 41(10):2051-61. DOI: 10.1016/j.biocel.2009.03.003. View

15.

Giusto M, Lattanzi B, Albanese C, Galtieri A, Farcomeni A, Giannelli V . Sarcopenia in liver cirrhosis: the role of computed tomography scan for the assessment of muscle mass compared with dual-energy X-ray absorptiometry and anthropometry. Eur J Gastroenterol Hepatol. 2015; 27(3):328-34. DOI: 10.1097/MEG.0000000000000274. View

16.

Glass C, Hipskind P, Tsien C, Malin S, Kasumov T, Shah S . Sarcopenia and a physiologically low respiratory quotient in patients with cirrhosis: a prospective controlled study. J Appl Physiol (1985). 2013; 114(5):559-65. PMC: 3615594. DOI: 10.1152/japplphysiol.01042.2012. View

17.

Shan T, Liang X, Bi P, Kuang S . Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5 pathway in muscle. FASEB J. 2013; 27(5):1981-9. PMC: 3633817. DOI: 10.1096/fj.12-225755. View

18.

Dasarathy S . Posttransplant sarcopenia: an underrecognized early consequence of liver transplantation. Dig Dis Sci. 2013; 58(11):3103-11. PMC: 4066193. DOI: 10.1007/s10620-013-2791-x. View

19.

Merli M, Giusto M, Lucidi C, Giannelli V, Pentassuglio I, Di Gregorio V . Muscle depletion increases the risk of overt and minimal hepatic encephalopathy: results of a prospective study. Metab Brain Dis. 2012; 28(2):281-4. DOI: 10.1007/s11011-012-9365-z. View

20.

Nishikawa H, Enomoto H, Ishii A, Iwata Y, Miyamoto Y, Ishii N . Elevated serum myostatin level is associated with worse survival in patients with liver cirrhosis. J Cachexia Sarcopenia Muscle. 2017; 8(6):915-925. PMC: 5700437. DOI: 10.1002/jcsm.12212. View