DNA Replication Stress and Cancer Chemotherapy

Overview

Journal Cancer Sci

Specialty Oncology

Date 2017 Nov 24

PMID 29168596

Citations 49

Authors

Hiroyuki Kitao

Makoto Iimori

Yuki Kataoka

Takeshi Wakasa

Eriko Tokunaga

Hiroshi Saeki

Eiji Oki

Yoshihiko Maehara

Affiliations

Soon will be listed here.

Abstract

DNA replication is one of the fundamental biological processes in which dysregulation can cause genome instability. This instability is one of the hallmarks of cancer and confers genetic diversity during tumorigenesis. Numerous experimental and clinical studies have indicated that most tumors have experienced and overcome the stresses caused by the perturbation of DNA replication, which is also referred to as DNA replication stress (DRS). When we consider therapeutic approaches for tumors, it is important to exploit the differences in DRS between tumor and normal cells. In this review, we introduce the current understanding of DRS in tumors and discuss the underlying mechanism of cancer therapy from the aspect of DRS.

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